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Acute resveratrol s...
Acute resveratrol supplementation in coronary artery disease : towards patient stratification
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- Díaz, Miguel, Högskoleadjunkt (författare)
- Röda Korsets Högskola,Hälsovetenskapliga institutionen,Manchester Metropolitan University, UK
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- Avila, A (författare)
- Manchester Metropolitan University, UK / KU Leuven, Belgium
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- Degens, H (författare)
- Manchester Metropolitan University, UK / Lithuanian Sports University, Lithuania
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- Coeckelberghs, E (författare)
- KU Leuven, Belgium
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- Vanhees, L (författare)
- KU Leuven, Belgium
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- Cornelissen, V (författare)
- KU Leuven, Belgium
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- Azzawi, M (författare)
- Manchester Metropolitan University, UK
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(creator_code:org_t)
- 2019-08-30
- 2020
- Engelska.
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Ingår i: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; :1, s. 14-19
- Relaterad länk:
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https://e-space.mmu....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- OBJECTIVE: Resveratrol (RV) is a polyphenol with antioxidant, anti-inflammatory and cardio-protective properties. Our objective was to investigate whether acute supplementation with high doses of RV would improve flow-mediated dilation (FMD) and oxygen consumption (VO2) kinetics in older coronary artery disease (CAD) patients.DESIGN: We employed a placebo-controlled, single-blind, crossover design in which ten participants (aged 66.6 ± 7.8 years) received either RV or placebo (330 mg, 3x day-1) during three consecutive days plus additional 330 mg in the morning of the fourth day with a seven-day wash-out period in-between. On the fourth day, FMD of the brachial artery and VO2 on-kinetics were determined. Results; RV improved FMD in patients who had undergone coronary artery bypass grafting (CABG; -1.4 vs. 5.0%; p = 0.004), but not in those who had undergone percutaneous coronary intervention (PCI; 4.2 vs. -0.2%; NS).CONCLUSION: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Aging
- Antioxidant
- Endothelial Dysfunction
- Oxygen Uptake
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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