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The Homeobox Genes ...
The Homeobox Genes of Caenorhabditis elegans and Insights into Their Spatio-Temporal Expression Dynamics during Embryogenesis
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- Hench, Jürgen (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Institutet
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- Henriksson, Johan (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Instiututet
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- Abou-Zied, Akram M (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Institutet
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- Lüppert, Martin (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Instiutetet
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- Dethlefsen, Johan (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Institutet
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- Mukherjee, Krishanu (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Intitutet
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- Tong, Yong Guang (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Intitutet
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- Tang, Lois (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Institutet
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- Gangishetti, Umesh (author)
- Karolinska Institutet
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- Baillie, David L (author)
- Simon Fraser University, Burnaby, British Columbia, Canada
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- Bürglin, Thomas R (author)
- Södertörns högskola,Institutionen för naturvetenskap, miljö och teknik,Karolinska Institutet
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(creator_code:org_t)
- 2015-05-29
- 2015
- English.
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In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 10:5
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Abstract
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- Homeobox genes play crucial roles for the development of multicellular eukaryotes. We have generated a revised list of all homeobox genes for Caenorhabditis elegans and provide a nomenclature for the previously unnamed ones. We show that, out of 103 homeobox genes, 70 are co-orthologous to human homeobox genes. 14 are highly divergent, lacking an obvious ortholog even in other Caenorhabditis species. One of these homeobox genes encodes 12 homeodomains, while three other highly divergent homeobox genes encode a novel type of double homeodomain, termed HOCHOB. To understand how transcription factors regulate cell fate during development, precise spatio-temporal expression data need to be obtained. Using a new imaging framework that we developed, Endrov, we have generated spatio-temporal expression profiles during embryogenesis of over 60 homeobox genes, as well as a number of other developmental control genes using GFP reporters. We used dynamic feedback during recording to automatically adjust the camera exposure time in order to increase the dynamic range beyond the limitations of the camera. We have applied the new framework to examine homeobox gene expression patterns and provide an analysis of these patterns. The methods we developed to analyze and quantify expression data are not only suitable for C. elegans, but can be applied to other model systems or even to tissue culture systems.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hench, Jürgen
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Henriksson, Joha ...
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Abou-Zied, Akram ...
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Lüppert, Martin
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Dethlefsen, Joha ...
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Mukherjee, Krish ...
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Tong, Yong Guang
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Tang, Lois
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Gangishetti, Ume ...
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Baillie, David L
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Bürglin, Thomas ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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PLOS ONE
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Södertörn University
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Karolinska Institutet