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Regulation of body ...
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Lateef, Dalya M.
(author)
Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3
- Article/chapterEnglish2014
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American Physiological Society,2014
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LIBRIS-ID:oai:DiVA.org:su-102966
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102966URI
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https://doi.org/10.1152/ajpendo.00615.2013DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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AuthorCount:4;
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Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, with Brs3 knockout (Brs3(-/y)) mice being hypometabolic, hypothermic, and hyperphagic and developing obesity. We now report that the reduced body temperature is more readily detected if body temperature is analyzed as a function of physical activity level and light/dark phase. Physical activity level correlated best with body temperature 4 min later. The Brs3(-/y) metabolic phenotype is not due to intrinsically impaired brown adipose tissue function or in the communication of sympathetic signals from the brain to brown adipose tissue, since Brs3(-/y) mice have intact thermogenic responses to stress, acute cold exposure, and beta 3-adrenergic activation, and Brs3(-/y) mice prefer a cooler environment. Treatment with the BRS-3 agonist MK-5046 increased brown adipose tissue temperature and body temperature in wild-type but not Brs3(-/y) mice. Intrahypothalamic infusion of MK5046 increased body temperature. These data indicate that the BRS-3 regulation of body temperature is via a central mechanism, upstream of sympathetic efferents. The reduced body temperature in Brs3(-/y) mice is due to altered regulation of energy homeostasis affecting higher center regulation of body temperature, rather than an intrinsic defect in brown adipose tissue.
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Abreu-Vieira, GustavoStockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut(Swepub:su)gdeab
(author)
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Xiao, Cuiying
(author)
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Reitman, Marc L.
(author)
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Stockholms universitetInstitutionen för molekylär biovetenskap, Wenner-Grens institut
(creator_code:org_t)
Related titles
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In:American Journal of Physiology. Endocrinology and Metabolism: American Physiological Society306:6, s. E681-E6870193-18491522-1555
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