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Linear energy transfer painting with proton therapy : a means of reducing radiation doses with equivalent clinical effectiveness
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- Fager, Marcus (author)
- Stockholms universitet,Fysikum,University of Pennsylvania, Philadelphia
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- Toma-Dasu, Iuliana (author)
- Stockholms universitet,Fysikum,Karolinska Institutet, Sweden
- Kirk, Maura (author)
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- Dolney, Derek (author)
- Diffenderfer, Eric S. (author)
- Vapiwala, Neha (author)
- Carabe, Alejandro (author)
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- (creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
- In: International Journal of Radiation Oncology, Biology, Physics. - : Elsevier BV. - 0360-3016 .- 1879-355X. ; 91:5, s. 1057-1064
- Journal article (peer-reviewed)
Abstract
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- Purpose: The purpose of this study was to propose a proton treatment planning method that trades physical dose (D) for dose-averaged linear energy transfer (LETd) while keeping the radiobiologically weighted dose (DRBE) to the target the same.Methods and Materials: The target is painted with LETd by using 2, 4, and 7 fields aimed at the proximal segment of the target (split target planning [STP]). As the LETd within the target increases with increasing number of fields, D decreases to maintain the DRBE the same as the conventional treatment planning method by using beams treating the full target (full target planning [FTP]).Results: The LETd increased 61% for 2-field STP (2STP) compared to FTP, 72% for 4STP, and 82% for 7STP inside the target. This increase in LETd led to a decrease of D with 5.3 ± 0.6 Gy for 2STP, 4.4 ± 0.7 Gy for 4STP, and 5.3 ± 1.1 Gy for 7STP, keeping the DRBE at 90% of the volume (DRBE, 90) constant to FTP.Conclusions: LETd painting offers a method to reduce prescribed dose at no cost to the biological effectiveness of the treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- medicinsk strålningsfysik
- Medical Radiation Physics
- onkologi
- Oncology
- Radiation Physics
- radiofysik
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- ref (subject category)
- art (subject category)
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