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Regional lung venti...
Regional lung ventilation in humans during hypergravity studied with quantitative SPECT
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- Ax, M. (författare)
- Karolinska Institutet
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- Karlsson, L. L. (författare)
- Karolinska Institutet
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- Sanchez-Crespo, Alejandro (författare)
- Stockholms universitet,Medicinsk strålningsfysik (tills m KI),Karolinska University Hospital Solna, Sweden
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Lindahl, S. G. E. (författare)
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- Linnarsson, D. (författare)
- Karolinska Institutet
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Mure, M. (författare)
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- Petersson, J. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Respiratory Physiology & Neurobiology. - : Elsevier BV. - 1569-9048 .- 1878-1519. ; 189:3, s. 558-564
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Recently we challenged the view that arterial desaturation during hypergravity is caused by redistribution of blood flow to dependent lung regions by demonstrating a paradoxical redistribution of blood flow towards non-dependent regions. We have now quantified regional ventilation in 10 healthy supine volunteers at normal and three times normal gravity (1G and 3G). Regional ventilation was measured with Technegas (Tc-99m) and quantitative single photon emission computed tomography (SPECT). Hypergravity caused arterial desaturation, mean decrease 8%, p<0.05 vs. 1G. The ratio for mean ventilation per voxel for non-dependent and dependent lung regions was 0.81+/-0.12 during 1G and 1.63+/-0.35 during 3G (mean+/-SD), p<0.0001. Thus, regional ventilation was shifted from dependent to non-dependent regions. We suggest that arterial desaturation during hypergravity is caused by quantitatively different redistributions of blood flow and ventilation. To our knowledge, this is the first study presenting high-resolution measurements of regional ventilation in humans breathing normally during hypergravity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- Human centrifuge
- Technetium
- Technegas
- Ventilation-to-perfusion mismatch
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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