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Cellular Traffickin...
Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes
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Valdes, Raúl (author)
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Armijo, Alicia (author)
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Muñoz, Patricia (author)
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- Hultenby, Kjell (author)
- Karolinska Institutet
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Hagg, Andres (author)
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- Inzunza, Jose (author)
- Karolinska Institutet
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- Nalvarte, Ivan (author)
- Karolinska Institutet
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- Varshney, Mukesh (author)
- Karolinska Institutet
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- Mannervik, Bengt (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
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Segura-Aguilar, Juan (author)
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(creator_code:org_t)
- 2021-02-08
- 2021
- English.
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In: Neurotoxicity research. - : Springer Science and Business Media LLC. - 1029-8428 .- 1476-3524. ; 39:2, s. 182-190
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The enzyme glutathione transferase M2-2, expressed in human astrocytes, increases its expression in the presence of aminochrome and catalyzes the conjugation of aminochrome, preventing its toxic effects. Secretion of the enzyme glutathione transferase M2-2 from U373MG cells, used as a cellular model for astrocytes, has been reported, and the enzyme is taken up by neuroblastoma SYSH-S7 cells and provide protection against aminochrome. The present study provides evidence that glutathione transferase M2-2 is released in exosomes from U373MG cells, thereby providing a means for intercellular transport of the enzyme. With particular relevance to Parkinson disease and other degenerative conditions, we propose a new mechanism by which astrocytes may protect dopaminergic neurons against the endogenous neurotoxin aminochrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Astrocytes
- Exosomes
- Aminochrome
- Dopamine
- Neuroprotection
- Parkinson´s disease
- Dopaminergic neurons
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Valdes, Raúl
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Armijo, Alicia
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Muñoz, Patricia
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Hultenby, Kjell
-
Hagg, Andres
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Inzunza, Jose
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show more...
-
Nalvarte, Ivan
-
Varshney, Mukesh
-
Mannervik, Bengt
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Segura-Aguilar, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Neurotoxicity re ...
- By the university
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Stockholm University
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Karolinska Institutet