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Assessing Environme...
Assessing Environmental Risks during the Drug Development Process for Parasitic Vector-Borne Diseases : A Critical Reflection
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Ilbeigi, Kayhan (författare)
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Barata, Carlos (författare)
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Barbosa, João (författare)
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- Bertram, Michael G. (författare)
- Sveriges lantbruksuniversitet,Stockholms universitet,Zoologiska institutionen,Swedish University of Agricultural Sciences, Sweden; Monash University, Australia,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Stockholm University,Monash University
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Caljon, Guy (författare)
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Costi, Maria Paola (författare)
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Kroll, Alexandra (författare)
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Margiotta-Casaluci, Luigi (författare)
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- Thoré, Eli S. J. (författare)
- Sveriges lantbruksuniversitet,Stockholms universitet,Zoologiska institutionen,Swedish University of Agricultural Sciences, Sweden; KU Leuven, Belgium,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Stockholm University,University of Leuven (KU Leuven)
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- Bundschuh, Mirco (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vatten och miljö,Department of Aquatic Sciences and Assessment,University of Kaiserslautern-Landau (RPTU)
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(creator_code:org_t)
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- 2024
- 2024
- Engelska.
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Ingår i: ACS - Infectious Diseases. - 2373-8227. ; 10:4, s. 1026-1033
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://res.slu.se/i...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- Parasitic vector-borne diseases (VBDs) represent nearly 20% of the global burden of infectious diseases. Moreover, the spread of VBDs is enhanced by global travel, urbanization, and climate change. Treatment of VBDs faces challenges due to limitations of existing drugs, as the potential for side effects in nontarget species raises significant environmental concerns. Consequently, considering environmental risks early in drug development processes is critically important. Here, we examine the environmental risk assessment process for veterinary medicinal products in the European Union and identify major gaps in the ecotoxicity data of these drugs. By highlighting the scarcity of ecotoxicological data for commonly used antiparasitic drugs, we stress the urgent need for considering the One Health concept. We advocate for employing predictive tools and nonanimal methodologies such as New Approach Methodologies at early stages of antiparasitic drug research and development. Furthermore, adopting progressive approaches to mitigate ecological risks requires the integration of nonstandard tests that account for real-world complexities and use environmentally relevant exposure scenarios. Such a strategy is vital for a sustainable drug development process as it adheres to the principles of One Health, ultimately contributing to a healthier and more sustainable world.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Naturresursteknik -- Miljöledning (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Environmental Engineering -- Environmental Management (hsv//eng)
Nyckelord
- drug development
- environmental risk
- One Health
- parasitic vector-borne disease
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- ref (ämneskategori)
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