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Antioxidant airway ...
Antioxidant airway responses following experimental exposure to wood smoke in man
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- Sehlstedt, Maria, 1979- (författare)
- Umeå universitet,Lungmedicin
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- Dove, Rosamund (författare)
- Kings College London, MRC-HPA Centre for Environment and Health, School of Biomedical and Healthy Studies, King's College London, London, UK
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- Boman, Christoffer (författare)
- Umeå universitet,Energiteknik och termisk processkemi
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- Pagels, Joakim (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Division of Aerosol Technology, Lund University, Lund, Sweden
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- Swietlicki, Erik (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Kärnfysik,Fysiska institutionen,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Nuclear physics,Department of Physics,Faculty of Engineering, LTH,Department of Physics, Lund University, Lund, Sweden
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- Löndahl, Jakob (författare)
- Lund University,Lunds universitet,Ergonomi och aerosolteknologi,Institutionen för designvetenskaper,Institutioner vid LTH,Lunds Tekniska Högskola,Kärnfysik,Fysiska institutionen,Ergonomics and Aerosol Technology,Department of Design Sciences,Departments at LTH,Faculty of Engineering, LTH,Nuclear physics,Department of Physics,Faculty of Engineering, LTH,Department of Physics, Lund University, Lund, Sweden
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- Westerholm, Roger (författare)
- Stockholms universitet,Institutionen för analytisk kemi,Department of Analytical Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden
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- Bosson, Jenny (författare)
- Umeå universitet,Lungmedicin
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- Barath, Stefan (författare)
- Umeå universitet,Lungmedicin
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- Behndig, Annelie F (författare)
- Umeå universitet,Lungmedicin
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- Pourazar, Jamshid (författare)
- Umeå universitet,Lungmedicin
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- Sandström, Thomas (författare)
- Umeå universitet,Lungmedicin
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- Mudway, Ian S. (författare)
- Kings College London, MRC-HPA Centre for Environment and Health, School of Biomedical and Healthy Studies, King's College London, London, UK
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- Blomberg, Anders (författare)
- Umeå universitet,Lungmedicin
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(creator_code:org_t)
- 2010-08-20
- 2010
- Engelska.
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Ingår i: Particle and Fibre Toxicology. - : Springer Science and Business Media LLC. - 1743-8977. ; 7, s. 21-
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke PM under controlled conditions. Nineteen healthy volunteers were exposed to both wood smoke, at a particulate matter (PM2.5) concentration of 224 +/- 22 mu g/m(3), and filtered air for three hours with intermittent exercise. The wood smoke was generated employing an experimental set-up with an adjustable wood pellet boiler system under incomplete combustion. Symptoms, lung function, and exhaled NO were measured over exposures, with bronchoscopy performed 24 h post-exposure for characterisation of airway inflammatory and antioxidant responses in airway lavages. Results: Glutathione (GSH) concentrations were enhanced in bronchoalveolar lavage (BAL) after wood smoke exposure vs. air (p = 0.025), together with an increase in upper airway symptoms. Neither lung function, exhaled NO nor systemic nor airway inflammatory parameters in BAL and bronchial mucosal biopsies were significantly affected. Conclusions: Exposure of healthy subjects to wood smoke, derived from an experimental wood pellet boiler operating under incomplete combustion conditions with PM emissions dominated by organic matter, caused an increase in mucosal symptoms and GSH in the alveolar respiratory tract lining fluids but no acute airway inflammatory responses. We contend that this response reflects a mobilisation of GSH to the air-lung interface, consistent with a protective adaptation to the investigated wood smoke exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- NATURAL SCIENCES
- NATURVETENSKAP
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Sehlstedt, Maria ...
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Dove, Rosamund
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Boman, Christoff ...
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Pagels, Joakim
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Swietlicki, Erik
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Löndahl, Jakob
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Westerholm, Roge ...
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Bosson, Jenny
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Barath, Stefan
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Behndig, Annelie ...
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Pourazar, Jamshi ...
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Sandström, Thoma ...
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Mudway, Ian S.
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Blomberg, Anders
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Stockholms universitet
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Umeå universitet