Search: onr:"swepub:oai:DiVA.org:su-67274" >
Synthesis and alpha...
-
Cumpstey, IanStockholms universitet,Institutionen för organisk kemi
(author)
Synthesis and alpha-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis
- Article/chapterEnglish2011
Publisher, publication year, extent ...
-
Elsevier BV,2011
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:su-67274
-
https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-67274URI
-
https://doi.org/10.1016/j.bmcl.2011.07.046DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
authorCount :5
-
Valienol-derived allylic C-1 bromides have been used as carbaglycosyl donors for alpha-xylo configured valienamine pseudodisaccharide synthesis. We synthesised valienamine analogues of the Glc(alpha 1 -> 3)Glc and Glc(alpha 1 -> 3) Man disaccharides representing the linkages cleaved by alpha-Glucosidase II in N-glycan biosynthesis. These (N1 -> 3)-linked pseudodisaccharides were found to have some alpha-Glucosidase II inhibitory activity, while two other (N1 -> 6)-linked valienamine pseudodisaccharides failed to inhibit the enzyme. (C)
Subject headings and genre
-
alpha-Glucosidase II
-
Glycosidase inhibitors
-
Valienamine
-
Pseudodisaccharides
-
N-Glycans
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ramstadius, Clinton
(author)
-
Borbas, K. EszterStockholms universitet,Institutionen för organisk kemi(Swepub:su)eborb
(author)
-
Alonzi, Dominic S.
(author)
-
Butters, Terry D.
(author)
-
Stockholms universitetInstitutionen för organisk kemi
(creator_code:org_t)
Related titles
-
In:Bioorganic & Medicinal Chemistry Letters: Elsevier BV21:18, s. 5219-52230960-894X1464-3405
Internet link
Find in a library
To the university's database