Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening

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Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening

Dubicke, Aurelija (author): Karolinska Institutet,Department of Woman and Child Health, Karolinska Institute. Stockholm, Sweden

Sverremark-Ekström, Eva, 1968- (author): Stockholms universitet

Fransson, Emma, PhD, 1973- (author): Karolinska Institutet,Department of Woman and Child Health, Karolinska Institutet, Stockholm, Sweden

Centini, Gabriela (author): Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, 53100 Siena, Ital

Andersson, Eva (author): Karolinska Institutet,Department of Woman and Child Health, Karolinska Institute. Stockholm, Sweden

Byström, Birgitta (author): Karolinska Institutet,Department of Woman and Child Health, Karolinska Institute. Stockholm, Sweden

Ekman-Ordeberga, Gunvor (author): Karolinska Institutet,Department of Woman and Child Health, Karolinska Institute, Stockholm, Sweden

Malmström, Anders (author): Lund University,Lunds universitet,Matrixbiologi,Forskargrupper vid Lunds universitet,Matrix Biology,Lund University Research Groups,Department of Experimental Medical Science, University of Lund, 221 84 Lund, Sweden

Petraglia, Felice (author): Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, 53100 Siena, Italy

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Karolinska Institutet Department of Woman and Child Health, Karolinska Institute Stockholm, Sweden (creator_code:org_t)

Elsevier, 2010
2010
English.
In: Journal of Reproductive Immunology. - : Elsevier. - 0165-0378 .- 1872-7603. ; 84:2, s. 176-185

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Journal article (peer-reviewed)

Abstract Subject headings

Cervical ripening is necessary for successful delivery. Since cytokines are believed to be involved in this process, the aim of this study was to investigate possible changes in the mRNA and protein expression of pro-inflammatory cytokines (interleukin (IL)-1 alpha, IL-1 beta, IL-12, IL-18) and anti-inflammatory cytokines (IL-4, IL-10, IL-13)in the human cervix during pregnancy, term and preterm labor. Cervical biopsies were taken from 59 women: 21 at preterm labor, 24 at term labor, 10 at term not in labor and 4 from non-pregnant women. mRNA was analyzed with real-time RT-PCR and protein expression and/or secretion with immunohistochemistry and ELISA. There was an upregulation of mRNA for IL-10, IL-13, IL-1 alpha and IL-1 beta in the laboring groups, while mRNA for IL-12 and IL-18 was downregulated. IL-4 mRNA was detected more frequently, while IL-12 mRNA expression was lower, in the preterm labor group than in the term labor group. The protein levels of IL-4 and IL-12 were lower and IL-18 tended to be higher in the labor groups, while IL-10 protein levels were unaffected by labor. IL-4 protein levels were significantly higher in the preterm subgroup with bacterial infection than in the non-infected group. IL-10 had higher expression in squamous epithelium at preterm labor than at term. In conclusion, the major changes in pro-inflammatory and anti-inflammatory cytokine mRNA and protein expression in cervix occur during the labor process irrespective of the length of gestation. Our results indicate that dysregulation of anti-inflammatory cytokines in the human cervix could be involved in the pathogenesis of preterm labor.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

immunologi
Immunology
immunologi
Immunology
Preterm birth
Cytokines
Cervical ripening
Cervix

Publication and Content Type

ref (subject category)
art (subject category)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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