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N-Acyl taurines tri...
N-Acyl taurines trigger insulin secretion by increasing calcium flux in pancreatic beta-cells
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- Waluk, Dominik P. (författare)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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- Vielfort, Katarina (författare)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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- Derakhshan, Sepide (författare)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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- Aro, Helena (författare)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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Hunt, Mary C. (författare)
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 430:1, s. 54-59
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Pancreatic beta-cells secrete insulin in response to various stimuli to control blood glucose levels. This insulin release is the result of a complex interplay between signaling, membrane potential and intracellular calcium levels. Various nutritional and hormonal factors are involved in regulating this process. N-Acyl taurines are a group of fatty acids which are amidated (or conjugated) to taurine and little is known about their physiological functions. In this study, treatment of pancreatic beta-cell lines (HIT-T15) and rat islet cell lines (INS-1) with N-acyl taurines (N-arachidonoyl taurine and N-oleoyl taurine), induced a high frequency of calcium oscillations in these cells. Treatment with N-arachidonoyl taurine and N-oleoyl taurine also resulted in a significant increase in insulin secretion from pancreatic beta-cell lines as determined by insulin release assay and immunofluorescence (p < 0.05). Our data also show that the transient receptor potential vanilloid 1 (TRPV1) channel is involved in insulin secretion in response to N-arachidonoyl taurine and N-oleoyl taurine treatment. However our data also suggest that receptors other than TRPV1 are involved in the insulin secretion response to treatment with N-oleoyl taurine.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Nyckelord
- N-Arachidonoyl taurine
- N-Oleoyl taurine
- Insulin secretion
- Transient receptor potential vanilloid
- receptor 1 (TRPV1)
- Pancreatic beta-cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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