Sökning: onr:"swepub:oai:DiVA.org:umu-106567" > Genetic risk varian...
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000 | 05223naa a2200745 4500 | |
001 | oai:DiVA.org:umu-106567 | |
003 | SwePub | |
008 | 150720s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:131504241 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1065672 URI |
024 | 7 | a https://doi.org/10.1186/s13058-015-0596-x2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1315042412 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Campa, Daniele4 aut |
245 | 1 0 | a Genetic risk variants associated with in situ breast cancer |
264 | c 2015-06-13 | |
264 | 1 | b Springer Science and Business Media LLC,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS.Methods: To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), associated with risk of invasive BC, in 1317 BCIS cases, 10,645 invasive BC cases, and 14,006 healthy controls in the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium (BPC3). Using unconditional logistic regression models adjusted for age and study, we estimated the association of SNPs with BCIS using two different comparison groups: healthy controls and invasive BC subjects to investigate whether BCIS and BC share a common genetic profile.Results: We found that five SNPs (CDKN2BAS-rs1011970, FGFR2-rs3750817, FGFR2-rs2981582, TNRC9-rs3803662, 5p12-rs10941679) were significantly associated with BCIS risk (P value adjusted for multiple comparisons <0.0016). Comparing invasive BC and BCIS, the largest difference was for CDKN2BAS-rs1011970, which showed a positive association with BCIS (OR = 1.24, 95 % CI: 1.11-1.38, P = 1.27 x 10(-4)) and no association with invasive BC (OR = 1.03, 95 % CI: 0.99-1.07, P = 0.06), with a P value for case-case comparison of 0.006. Subgroup analyses investigating associations with ductal carcinoma in situ (DCIS) found similar associations, albeit less significant (OR = 1.25, 95 % CI: 1.09-1.42, P = 1.07 x 10(-3)). Additional risk analyses showed significant associations with invasive disease at the 0.05 level for 28 of the alleles and the OR estimates were consistent with those reported by other studies.Conclusions: Our study adds to the knowledge that several of the known BC susceptibility loci are risk factors for both BCIS and invasive BC, with the possible exception of rs1011970, a putatively functional SNP situated in the CDKN2BAS gene that may be a specific BCIS susceptibility locus. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Barrdahl, Myrto4 aut |
700 | 1 | a Gaudet, Mia M.4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Diver, W. Ryan4 aut |
700 | 1 | a Gapstur, Susan M.4 aut |
700 | 1 | a Haiman, Christopher4 aut |
700 | 1 | a Hankinson, Susan4 aut |
700 | 1 | a Hazra, Aditi4 aut |
700 | 1 | a Henderson, Brian4 aut |
700 | 1 | a Hoover, Robert N.4 aut |
700 | 1 | a Hunter, David J.4 aut |
700 | 1 | a Joshi, Amit D.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Lindstrom, Sara4 aut |
700 | 1 | a Willett, Walter4 aut |
700 | 1 | a Travis, Ruth C.4 aut |
700 | 1 | a Amiano, Pilar4 aut |
700 | 1 | a Siddiq, Afshan4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Sund, Malinu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Ziegler, Regina G.4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
710 | 2 | a Umeå universitetb Kirurgi4 org |
773 | 0 | t Breast Cancer Researchd : Springer Science and Business Media LLCg 17q 17x 1465-5411x 1465-542X |
856 | 4 | u https://doi.org/10.1186/s13058-015-0596-xy Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:842484/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-015-0596-x |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-106567 |
856 | 4 8 | u https://doi.org/10.1186/s13058-015-0596-x |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131504241 |
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