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Prospective associa...
Prospective association of liver function biomarkers with development of hepatobiliary cancers
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- Stepien, Magdalena (author)
- International Agency for Research on Cancer, World Health Organization
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- Fedirko, Veronika (author)
- Emory University
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- Duarte-Salles, Talita (author)
- International Agency for Research on Cancer, World Health Organization
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- Ferrari, Pietro (author)
- International Agency for Research on Cancer, World Health Organization
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- Freisling, Heinz (author)
- International Agency for Research on Cancer, World Health Organization
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- Trepo, Elisabeth (author)
- Laboratoire Lyon République
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- Trichopoulou, Antonia (author)
- Hellenic Health Foundation, Athens
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- Bamia, Christina (author)
- Hellenic Health Foundation, Athens
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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- Olsen, Anja (author)
- Danish Cancer Society
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Tjonneland, Anne (author)
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Overvad, Kim (author)
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Boutron-Ruault, Marie-Christine (author)
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Fagherazzi, Guy (author)
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Racine, Antoine (author)
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Kuehn, Tilman (author)
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Kaaks, Rudolf (author)
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Aleksandrova, Krasimira (author)
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Boeing, Heiner (author)
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Lagiou, Pagona (author)
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Benetou, Vassiliki (author)
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Trichopoulos, Dimitrios (author)
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Palli, Domenico (author)
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Grioni, Sara (author)
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Tumino, Rosario (author)
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Naccarati, Alessio (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H. Bas (author)
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Peeters, Petra H. (author)
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Lund, Eiliv (author)
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Quiros, J. Ramon (author)
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Napoles, Osmel Companioni (author)
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Sanchez, Maria-Jose (author)
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Dorronsoro, Miren (author)
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Maria Huerta, Jose (author)
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Ardanaz, Eva (author)
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- Ohlsson, Bodil (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Sjöberg, Klas (author)
- Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
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- Werner, Mårten (author)
- Umeå universitet,Medicin
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- Nyström, Hanna (author)
- Umeå universitet,Kirurgi
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Khaw, Kay-Tee (author)
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Key, Timothy J. (author)
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Gunter, Marc (author)
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Cross, Amanda (author)
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Riboli, Elio (author)
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Romieu, Isabelle (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
- Elsevier, 2016
- 2016
- English.
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In: Cancer Epidemiology. - : Elsevier. - 1877-7821 .- 1877-783X. ; 40, s. 179-187
- Related links:
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http://spiral.imperi...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Introduction: Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods: A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10 European countries). After a mean 7.5 mean years of follow-up, 121 hepatocellular carcinoma (HCC), 34 intrahepatic bile duct (IHBC) and 131 gallbladder and biliary tract (GBTC) cases were identified and matched to 2 controls each. Circulating biomarkers were measured in serum taken at recruitment into the cohort, prior to cancer diagnosis. Multivariable adjusted conditional logistic regression was used to calculate odds ratios and 95% confidence intervals (OR; 95% CI). Results: In multivariable models, 1SD increase of each log-transformed biomarker was positively associated with HCC risk (OR(GGT) = 4.23, 95% CI: 2.72-6.59; OR(ALP) = 3.43, 95% CI: 2.31-5.10; OR(AST) = 3.00, 95% CI: 2.04-4.42; OR(ALT) = 2.69, 95% CI: 1.89-3.84; OR(Bilirubin) = 2.25, 95% CI: 1.58-3.20). Each liver enzyme (OR(GGT) = 4.98; 95% CI: 1.75-14.17; OR(AST) = 3.10, 95% CI: 1.04-9.30; OR(ALT) = 2.86, 95% CI: 1.26-6.48, OR(ALP) = 2.31, 95% CI: 1.10-4.86) but not bilirubin (OR(Bilirubin) = 1.46,95% CI: 0.85-2.51) showed a significant association with IHBC. Only ALP was significantly associated with GBTC risk (OR (ALP) = 1.59, 95% CI: 1.20-2.09). Conclusion: This study shows positive associations between circulating liver biomarkers in sera collected prior to cancer diagnoses and the risks of developing HCC or IHBC, but not GBTC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Hepatobiliary cancer
- Liver function test
- Biological markers
- Prospective cohort
- Nested case-control udy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stepien, Magdale ...
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Fedirko, Veronik ...
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Duarte-Salles, T ...
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Ferrari, Pietro
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Freisling, Heinz
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Trepo, Elisabeth
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show more...
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Trichopoulou, An ...
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Bamia, Christina
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Weiderpass, Elis ...
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Olsen, Anja
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Tjonneland, Anne
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Overvad, Kim
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Boutron-Ruault, ...
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Fagherazzi, Guy
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Racine, Antoine
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Kuehn, Tilman
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Kaaks, Rudolf
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Aleksandrova, Kr ...
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Boeing, Heiner
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Lagiou, Pagona
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Benetou, Vassili ...
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Trichopoulos, Di ...
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Palli, Domenico
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Grioni, Sara
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Tumino, Rosario
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Naccarati, Aless ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Lund, Eiliv
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Quiros, J. Ramon
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Napoles, Osmel C ...
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Sanchez, Maria-J ...
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Dorronsoro, Mire ...
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Maria Huerta, Jo ...
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Ardanaz, Eva
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Ohlsson, Bodil
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Sjöberg, Klas
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Werner, Mårten
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Nyström, Hanna
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Khaw, Kay-Tee
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Key, Timothy J.
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Gunter, Marc
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Cross, Amanda
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Riboli, Elio
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Romieu, Isabelle
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Jenab, Mazda
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Cancer Epidemiol ...
- By the university
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Umeå University
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Lund University
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Karolinska Institutet