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Expression of the N...
Expression of the NK-1 receptor on islet cells and invading immune cells in the non-obese diabetic mouse
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- Persson-Sjögren, Solveig (författare)
- Umeå universitet,Histologi med cellbiologi
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- Lejon, Kristina, 1967- (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Holmberg, Dan, 1954- (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Forsgren, Sture (författare)
- Umeå universitet,Anatomi
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(creator_code:org_t)
- Elsevier, 2005
- 2005
- Engelska.
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Ingår i: Journal of Autoimmunity. - : Elsevier. - 0896-8411. ; 24:4, s. 269-279
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The underlying mechanistic causes of immune cell infiltration in the islets of Langerhans and beta cell failure in the non-obese diabetic (NOD) mouse is still to be completely revealed. Substance P (SP) is a substance known to have pro-inflammatory, endocrine, neuromodulatory and trophic effects, and its preferred receptor, the neurokinin receptor 1 (NK-1 R), is reported to be involved in extravasation of granulocytes and in inflammation and tissue derangement. Therefore, we have investigated the expression of NK-1 R during development of insulitis in the NOD mouse. We show that the magnitude of immunoreactivity scoring NK-1 R expression in the islets was increased in the 12-week-old NOD mouse. Expression of NK-1 R co-localized with expression of glucagon. In line with this expression pattern, we did not detect any effect of SP on glucose-induced insulin release. NK-1 R expression was particularly observed in islet cells in association with the clusters of immune cells. Expression of NK-1 R was also demonstrated in a fraction of the infiltrating B and T lymphocytes, as well as on infiltrating macrophages and dendritic cells. The observations show that the level of NK-1 R expression is increased in 12-week-old NOD mice, being correlated with the occurrence of islet mononuclear infiltration. Our data suggest that SP may act as a chemoattractant, contributing to the pathogenic mononuclear infiltration process in the NOD mouse. On the whole, the observations suggest that SP and the NK-1 R to certain extents are involved in the changes that occur during the development of insulitis in the NOD mouse.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Animals
- Diabetes Mellitus; Type 1/immunology/pathology
- Gene Expression Regulation/*immunology
- Islets of Langerhans/*immunology/pathology
- Leukocytes/*immunology/pathology
- Mice
- Mice; Inbred NOD
- Receptors; Neurokinin-1/*biosynthesis/immunology
- Substance P/immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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