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Vessel co-option me...
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases
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Frentzas, Sophia (author)
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Simoneau, Eve (author)
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Bridgeman, Victoria L. (author)
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Vermeulen, Peter B. (author)
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Foo, Shane (author)
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Kostaras, Eleftherios (author)
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Nathan, Mark R. (author)
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Wotherspoon, Andrew (author)
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Gao, Zu-Hua (author)
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Shi, Yu (author)
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Van den Eynden, Gert (author)
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Daley, Frances (author)
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Peckitt, Clare (author)
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Tan, Xianming (author)
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Salman, Ayat (author)
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Lazaris, Anthoula (author)
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Gazinska, Patrycja (author)
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Berg, Tracy J. (author)
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Eltahir, Zak (author)
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Ritsma, Laila (author)
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van Rheenen, Jacco (author)
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Khashper, Alla (author)
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Brown, Gina (author)
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- Nyström, Hanna (author)
- Umeå universitet,Kirurgi
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- Sund, Malin (author)
- Umeå universitet,Kirurgi
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Van Laere, Steven (author)
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Loyer, Evelyne (author)
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Dirix, Luc (author)
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Cunningham, David (author)
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Metrakos, Peter (author)
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Reynolds, Andrew R. (author)
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(creator_code:org_t)
- 2016-10-17
- 2016
- English.
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In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 22:11, s. 1294-1302
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co-option. Here we show that vessel co-option is associated with a poor response to the anti-angiogenic agent bevacizumab in patients with colorectal cancer liver metastases. Moreover, we find that vessel co-option is also prevalent in human breast cancer liver metastases, a setting in which results with anti-angiogenic therapy have been disappointing. In preclinical mechanistic studies, we found that cancer cell motility mediated by the actin-related protein 2/3 complex (Arp2/3) is required for vessel co-option in liver metastases in vivo and that, in this setting, combined inhibition of angiogenesis and vessel co-option is more effective than the inhibition of angiogenesis alone. Vessel co-option is therefore a clinically relevant mechanism of resistance to anti-angiogenic therapy and combined inhibition of angiogenesis and vessel co-option might be a warranted therapeutic strategy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Frentzas, Sophia
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Simoneau, Eve
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Bridgeman, Victo ...
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Vermeulen, Peter ...
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Foo, Shane
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Kostaras, Elefth ...
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show more...
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Nathan, Mark R.
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Wotherspoon, And ...
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Gao, Zu-Hua
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Shi, Yu
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Van den Eynden, ...
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Daley, Frances
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Peckitt, Clare
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Tan, Xianming
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Salman, Ayat
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Lazaris, Anthoul ...
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Gazinska, Patryc ...
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Berg, Tracy J.
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Eltahir, Zak
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Ritsma, Laila
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van Rheenen, Jac ...
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Khashper, Alla
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Brown, Gina
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Nyström, Hanna
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Sund, Malin
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Van Laere, Steve ...
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Loyer, Evelyne
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Dirix, Luc
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Cunningham, Davi ...
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Metrakos, Peter
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Reynolds, Andrew ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Medicine
- By the university
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Umeå University