Sökning: onr:"swepub:oai:DiVA.org:umu-129264" > Regulation of embry...
Fältnamn | Indikatorer | Metadata |
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000 | 03225naa a2200565 4500 | |
001 | oai:DiVA.org:umu-129264 | |
003 | SwePub | |
008 | 161222s2012 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1292642 URI |
024 | 7 | a https://doi.org/10.1016/j.stem.2012.05.0202 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lee, Dung-Fang4 aut |
245 | 1 0 | a Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. |
264 | 1 | b Elsevier BV,c 2012 |
338 | a print2 rdacarrier | |
520 | a Many signals must be integrated to maintain self-renewal and pluripotency in embryonic stem cells (ESCs) and to enable induced pluripotent stem cell (iPSC) reprogramming. However, the exact molecular regulatory mechanisms remain elusive. To unravel the essential internal and external signals required for sustaining the ESC state, we conducted a short hairpin (sh) RNA screen of 104 ESC-associated phosphoregulators. Depletion of one such molecule, aurora kinase A (Aurka), resulted in compromised self-renewal and consequent differentiation. By integrating global gene expression and computational analyses, we discovered that loss of Aurka leads to upregulated p53 activity that triggers ESC differentiation. Specifically, Aurka regulates pluripotency through phosphorylation-mediated inhibition of p53-directed ectodermal and mesodermal gene expression. Phosphorylation of p53 not only impairs p53-induced ESC differentiation but also p53-mediated suppression of iPSC reprogramming. Our studies demonstrate an essential role for Aurka-p53 signaling in the regulation of self-renewal, differentiation, and somatic cell reprogramming. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Su, Jie4 aut |
700 | 1 | a Ang, Yen-Sin4 aut |
700 | 1 | a Carvajal-Vergara, Xonia4 aut |
700 | 1 | a Mulero-Navarro, Sonia4 aut |
700 | 1 | a Pereira, Carlos F4 aut |
700 | 1 | a Gingold, Julian4 aut |
700 | 1 | a Wang, Hung-Liang4 aut |
700 | 1 | a Zhao, Ruiying4 aut |
700 | 1 | a Sevilla, Ana4 aut |
700 | 1 | a Darr, Henia4 aut |
700 | 1 | a Williamson, Andrew J K4 aut |
700 | 1 | a Chang, Betty4 aut |
700 | 1 | a Niu, Xiaohong4 aut |
700 | 1 | a Aguilo, Francesca4 aut |
700 | 1 | a Flores, Elsa R4 aut |
700 | 1 | a Sher, Yuh-Pyng4 aut |
700 | 1 | a Hung, Mien-Chie4 aut |
700 | 1 | a Whetton, Anthony D4 aut |
700 | 1 | a Gelb, Bruce D4 aut |
700 | 1 | a Moore, Kateri A4 aut |
700 | 1 | a Snoeck, Hans-Willem4 aut |
700 | 1 | a Ma'ayan, Avi4 aut |
700 | 1 | a Schaniel, Christoph4 aut |
700 | 1 | a Lemischka, Ihor R4 aut |
773 | 0 | t Cell Stem Celld : Elsevier BVg 11:2q 11:2x 1934-5909x 1875-9777 |
856 | 4 | u http://www.cell.com/article/S1934590912003396/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129264 |
856 | 4 8 | u https://doi.org/10.1016/j.stem.2012.05.020 |
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