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Thyroid Cancer Foll...
Thyroid Cancer Following Childhood Low-Dose Radiation Exposure : A Pooled Analysis of Nine Cohorts
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Lubin, Jay H. (author)
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Adams, M. Jacob (author)
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Shore, Roy (author)
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Holmberg, Erik (author)
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Schneider, Arthur B. (author)
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Hawkins, Michael M. (author)
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Robison, Leslie L. (author)
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Inskip, Peter D. (author)
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Lundell, Marie (author)
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- Johansson, Robert (author)
- Umeå universitet,Onkologi
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Kleinerman, Ruth A. (author)
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de Vathaire, Florent (author)
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- Damber, Lena (author)
- Umeå universitet,Onkologi
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Sadetzki, Siegal (author)
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Tucker, Margaret (author)
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Sakata, Ritsu (author)
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Veiga, Lene H. S. (author)
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(creator_code:org_t)
- 2017-03-08
- 2017
- English.
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 102:7, s. 2575-2583
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Context: The increased use of diagnostic and therapeutic procedures that involve radiation raises concerns about radiation effects, particularly in children and the radiosensitive thyroid gland.Objectives: Evaluation of relative risk (RR) trends for thyroid radiation doses <0.2 gray (Gy); evidence of a threshold dose; and possible modifiers of the dose-response, e.g., sex, age at exposure, time since exposure.Design and Setting: Pooled data from nine cohort studies of childhood external radiation exposure and thyroid cancer with individualized dose estimates, ≥1000 irradiated subjects or ≥10 thyroid cancer cases, with data limited to individuals receiving doses <0.2 Gy.Participants: Cohorts included the following: childhood cancer survivors (n = 2); children treated for benign diseases (n = 6); and children who survived the atomic bombings in Japan (n = 1). There were 252 cases and 2,588,559 person-years in irradiated individuals and 142 cases and 1,865,957 person-years in nonirradiated individuals.Intervention: There were no interventions.Main Outcome Measure: Incident thyroid cancers.Results: For both <0.2 and <0.1 Gy, RRs increased with thyroid dose (P < 0.01), without significant departure from linearity (P = 0.77 and P = 0.66, respectively). Estimates of threshold dose ranged from 0.0 to 0.03 Gy, with an upper 95% confidence bound of 0.04 Gy. The increasing dose–response trend persisted >45 years after exposure, was greater at younger age at exposure and younger attained age, and was similar by sex and number of treatments.Conclusions: Our analyses reaffirmed linearity of the dose response as the most plausible relationship for “as low as reasonably achievable” assessments for pediatric low-dose radiation-associated thyroid cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Lubin, Jay H.
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Adams, M. Jacob
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Shore, Roy
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Holmberg, Erik
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Schneider, Arthu ...
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Hawkins, Michael ...
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show more...
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Robison, Leslie ...
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Inskip, Peter D.
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Lundell, Marie
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Johansson, Rober ...
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Kleinerman, Ruth ...
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de Vathaire, Flo ...
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Damber, Lena
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Sadetzki, Siegal
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Tucker, Margaret
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Sakata, Ritsu
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Veiga, Lene H. S ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Occupational Hea ...
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Journal of Clini ...
- By the university
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Umeå University
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Karolinska Institutet