International Survey of ALS Experts about Critical Questions for Assessing Patients with ALS

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MARC

De Carvalho, Mamede (author)

International Survey of ALS Experts about Critical Questions for Assessing Patients with ALS

Article/chapterEnglish2017

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2017-07-13
Taylor & Francis,2017
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LIBRIS-ID:oai:DiVA.org:umu-142684
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142684URI
https://doi.org/10.1080/21678421.2017.1349150DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Objective: To define an applicable dataset for ALS patient registries we weighted specific clinical items as scored by worldwide ALS experts.Methods: Sixty participants were invited based on relevant clinical work, publications and personal acquaintance. They rated 160 clinical items consensually agreed by the members of our project, incorporating specialists from five European Centres. Scoring scheme was defined as: 1 - essential; 2 - important; 3 - not very important. A mixed effect model was applied to rank items and to find possible correlations with geographical region (Europe vs. outside Europe).Results: We received 40 responses, 20 from Europe and 20 from outside; 42/160 data were scored as essential by >50% of the respondents, including: date of birth, gender, date of disease onset, date of diagnosis, ethnicity, region of onset, predominant upper neuron (UMN) or lower motor neuron (LMN) impairment, proximal versus distal weakness, respiratory symptoms, dysarthria, weight loss, signs of LMN/UMN involvement, emotional incontinence, cognitive changes, respiratory signs, neck weakness, body mass index, ALSFRS-R at entry, ALSFRS-R subscores at entry, timing and pattern of spreading and staging, electromyography, spirometry, MRI, CK level, riluzole intake, genetic background, history of physical exercise and previous and current main occupation. Four components were scored as non-relevant, including place of birth, blood pressure and pain at onset. There was no significant difference between regions (European vs. non-European countries).Conclusions: Our study identified a consensual set of clinical data with 42 specific items that can be used as a minimal data set for patient registers and for clinical trials.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Neurologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Neurology hsv//eng
amyotrophic lateral sclerosis
hierarchy
signals
survey
symptoms

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Ryczkowski, Adam (author)
Andersen, Peter M.Umeå universitet,Klinisk neurovetenskap(Swepub:umu)pean0001 (author)
Gromicho, Marta (author)
Grosskreutz, Julian (author)
Kuzma-Kozakiewicz, Magdalena (author)
Petri, Susanne (author)
Piotrkiewicz, Maria (author)
Miltenberger Miltenyi, Gabriel (author)
Umeå universitetKlinisk neurovetenskap (creator_code:org_t)

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In:Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration: Taylor & Francis18:7-8, s. 505-5102167-84212167-9223

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By the author/editor: De Carvalho, Mam ...; Ryczkowski, Adam; Andersen, Peter ...; Gromicho, Marta; Grosskreutz, Jul ...; Kuzma-Kozakiewic ...; show more...; Petri, Susanne; Piotrkiewicz, Ma ...; Miltenberger Mil ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

Articles in the publication: Amyotrophic Late ...

By the university: Umeå University

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