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Interaction between...
Interaction between Cytomegalovirus and Herpes Simplex Virus Type 1 Associated with the Risk of Alzheimer’s Disease Development
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- Lövheim, Hugo (författare)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umea Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umea, Sweden
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- Olsson, Jan (författare)
- Umeå universitet,Virologi,Umea Univ, Dept Clin Microbiol Virol, Umea, Sweden.
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- Weidung, Bodil (författare)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Uppsala, Sweden,Umea Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umea, Sweden
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- Johansson, Anders (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen,Umea Univ, Dept Clin Microbiol Virol, Umea, Sweden.;Umea Univ, Dept Odontol, Umea, Sweden.
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- Eriksson, Sture (författare)
- Umeå universitet,Näringsforskning,Geriatrik,Umea Univ, Dept Community Med & Rehabil, Geriatr Med, SE-90185 Umea, Sweden.;Umea Univ, Dept Clin Microbiol Virol, Umea, Sweden.
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning,Umea Univ, Dept Publ Hlth & Clin Med, Nutr Res, Umea, Sweden.
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- Elgh, Fredrik (författare)
- Umeå universitet,Virologi,Umea Univ, Dept Clin Microbiol Virol, Umea, Sweden.
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(creator_code:org_t)
- IOS PRESS, 2018
- 2018
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS PRESS. - 1387-2877 .- 1875-8908. ; 61, s. 939-945
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Several environmental factors, including infectious agents, have been suggested to cause Alzheimer's disease (AD). Cytomegalovirus (CMV) has been associated with AD in several recent studies.OBJECTIVE: To investigate whether carriage of CMV, alone or in combination with Herpes simplex virus (HSV), increased the risk of developing AD.METHODS: Plasma samples from 360 AD cases (75.3% women, mean age 61.2 years), taken an average of 9.6 years before AD diagnosis, and 360 age-, sex-, cohort-, and sampling date matched dementia-free controls were analyzed to detect anti-CMV (immunoglobulin [Ig] G and IgM), group-specific anti-HSV (IgG and IgM), and specific anti-HSV1 and HSV2 IgG antibodies by enzyme-linked immunosorbent assays. AD cases and dementia-free controls were compared using conditional logistic regression analyses.RESULTS: The presence of anti-CMV IgG antibodies did not increase the risk of AD (odds ratio [OR], 0.857; p = 0.497). Among AD cases, an association between CMV and HSV1 carriage was detected (OR 7.145, p < 0.001); in a conditional logistic regression model, the interaction between CMV and HSV1 was associated with AD development (OR 5.662; p = 0.007).CONCLUSION: The present findings do not support a direct relationship between CMV infection and the development of AD; however, an interaction between CMV and HSV1 was found to be associated significantly with AD development. These findings suggest that CMV infection facilitates the development of HSV1-associated AD, possibly via its effects on the immune system.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Alzheimer’s disease
- Herpes simplex virus
- cytomegalovirus
- dementia
- nested case-control study
- epidemiologi
- Epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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