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Antitumor Humoral a...
Antitumor Humoral and T Cell Responses by Mucin-1 Conjugates of Bacteriophage Qβ in Wild-type Mice
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Yin, Zhaojun (author)
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Wu, Xuanjun (author)
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Kaczanowska, Katarzyna (author)
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Sungsuwan, Suttipun (author)
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Comellas Aragones, Marta (author)
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- Pett, Christian (author)
- Umeå universitet,Kemiska institutionen
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Yu, Jin (author)
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Baniel, Claire (author)
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- Ulrika, Westerlind (author)
- Umeå universitet,Kemiska institutionen
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Finn, M. G. (author)
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Huang, Xuefei (author)
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(creator_code:org_t)
- 2018-05-21
- 2018
- English.
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In: ACS Chemical Biology. - : American Chemical Society. - 1554-8929 .- 1554-8937. ; 13:6, s. 1668-1676
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Mucin-1 (MUC1) is one of the top ranked tumor associated antigens. In order to generate effective anti-MUC1 immune responses as potential anticancer vaccines, MUC1 peptides and glycopeptides have been covalently conjugated to bacteriophage Qβ. Immunization of mice with these constructs led to highly potent antibody responses with IgG titers over one million, which are among the highest anti-MUC1 IgG titers reported to date. Furthermore, the high IgG antibody levels persisted for more than six months. The constructs also elicited MUC1 specific cytotoxic T cells, which can selectively kill MUC1 positive tumor cells. The unique abilities of Qβ-MUC1 conjugates to powerfully induce both antibody and cytotoxic T cell immunity targeting tumor cells bode well for future translation of the constructs as anticancer vaccines.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Yin, Zhaojun
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Wu, Xuanjun
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Kaczanowska, Kat ...
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Sungsuwan, Sutti ...
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Comellas Aragone ...
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Pett, Christian
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show more...
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Yu, Jin
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Baniel, Claire
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Ulrika, Westerli ...
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Finn, M. G.
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Huang, Xuefei
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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ACS Chemical Bio ...
- By the university
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Umeå University