Sökning: onr:"swepub:oai:DiVA.org:umu-151284" > Neoadjuvant Chemoth...
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000 | 06817naa a2200625 4500 | |
001 | oai:DiVA.org:umu-151284 | |
003 | SwePub | |
008 | 180831s2018 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-371038 | |
009 | oai:DiVA.org:liu-153150 | |
009 | oai:prod.swepub.kib.ki.se:139628883 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1512842 URI |
024 | 7 | a https://doi.org/10.1016/j.eururo.2018.06.0482 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3710382 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1531502 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1396288832 URI |
040 | a (SwePub)umud (SwePub)uud (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Krantz, Davidu Karolinska Institutet4 aut |
245 | 1 0 | a Neoadjuvant Chemotherapy Reinforces Antitumour T cell Response in Urothelial Urinary Bladder Cancer |
264 | 1 | b Elsevier,c 2018 |
338 | a print2 rdacarrier | |
500 | a Funding Agencies|Swedish Cancer Foundation; Wallenberg Foundation; Swedish Medical Research Council, Vinnova; Regionala forskningsradet in Uppsala-Orebroregionen (RFR in Uppsala-Orebro); Swedish Research Council; Cancer Research Foundation in Norrland, Umea, Sweden; Karolinska Research Network Program in Immune Modulatory Therapies for Autoimmunity and Cancer | |
520 | a Evidence indicates that neoadjuvant chemotherapy (NAC) may promote antitumour immune responses by activating T cells. The tumour-draining sentinel node (SN) is a key site to study tumour-specific T cell activation, being the primary immunological barrier against the tumour. In this prospective study, we set out to elucidate the effects of NAC on T cell subsets in the SNs of patients with muscle-invasive urothelial bladder cancer. We found that CD8+ effector T (Teff) cell exhaustion was reduced after NAC treatment, while cytotoxicity was increased. Additionally, in complete responders (CR patients), these cells were functionally committed effectors, as displayed by epigenetic analysis. In CD4+ Teffs, NAC treatment was associated with increased clonal expansion of tumour-specific SN-derived cells, as demonstrated by a specific cell reactivity assay. In contrast, we observed an attenuating effect of NAC on regulatory T cells (Tregs) with a dose-dependent decrease in Treg frequency and reduced effector molecule expression in the remaining Tregs. In addition, multicolour flow cytometry analysis revealed that CR patients had higher Teff to activated Treg ratio, promoting antitumoural T cell activation. These results suggest that NAC reinforces the antitumour immune response by activating the effector arm of the T cell compartment and diminishing the influence of suppressive Tregs.PATIENT SUMMARY: In this report, we analysed the effect of chemotherapy on immune cell subsets of 40 patients with advanced bladder cancer. We found that chemotherapy has a positive effect on immune effector T cells, whereas an opposite, diminishing effect was observed for immune-suppressive regulatory T cells. We conclude that chemotherapy reinforces the antitumour immune response in bladder cancer patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Chemotherapy | |
653 | a Sentinel node | |
653 | a T cells | |
653 | a Urothelial bladder cancer | |
700 | 1 | a Hartana, Ciputra Adijayau Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 aut |
700 | 1 | a Winerdal, Malin Eu Karolinska Institutet4 aut |
700 | 1 | a Johansson, Markusu Umeå universitet,Urologi och andrologi,Department of Urology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Urol, Sundsvall, Sweden;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden4 aut |
700 | 1 | a Alamdari, Farhoodu Vastmanland Hosp, Dept Urol, Vasteras, Sweden4 aut |
700 | 1 | a Jakubczyk, Tomaszu Ryhov Cty Hosp, Dept Urol, Jonkoping, Sweden4 aut |
700 | 1 | a Huge, Ylvau Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ylvhu61 |
700 | 1 | a Aljabery, Firasu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05 |
700 | 1 | a Palmqvist, Karinu Umeå universitet,Urologi och andrologi,Urology Section, Department of Surgery, Östersund County Hospital, Östersund, Sweden,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden;Ostersund Cty Hosp, Dept Surg, Urol Sect, Ostersund, Sweden4 aut |
700 | 1 | a Zirakzadeh, A. Aliu Umeå universitet,Urologi och andrologi,Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden4 aut0 (Swepub:umu)alizih97 |
700 | 1 | a Holmström, Bennyu Uppsala universitet,Urologkirurgi,Akad Univ Hosp, Sweden4 aut |
700 | 1 | a Riklund, Katrine,d 1963-u Umeå universitet,Diagnostisk radiologi,Umea Univ, Dept Radiat Sci, Diagnost Radiol, Umea, Sweden4 aut0 (Swepub:umu)kaah0001 |
700 | 1 | a Sherif, Amiru Linköpings universitet,Umeå universitet,Urologi och andrologi,Division of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden;Linkoping Univ, Dept Clin & Expt Med, Div Urol, Linkoping, Sweden,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten4 aut0 (Swepub:liu)amish64 |
700 | 1 | a Winqvist, Olau Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 org |
773 | 0 | t European Urologyd : Elsevierg 74:6, s. 688-692q 74:6<688-692x 0302-2838x 1873-7560 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151284 |
856 | 4 8 | u https://doi.org/10.1016/j.eururo.2018.06.048 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-371038 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153150 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:139628883 |
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