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Kallikrein-related ...
Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype
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Haddada, Meriem (author)
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Draoui, Hend (author)
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Deschamps, Lydia (author)
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Walker, Francine (author)
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Delaunay, Tiphaine (author)
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- Brattsand, Maria (author)
- Umeå universitet,Patologi
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Magdolen, Viktor (author)
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Darmoul, Dalila (author)
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(creator_code:org_t)
- 2018-03-02
- 2018
- English.
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In: Biological chemistry (Print). - : Walter de Gruyter. - 1431-6730 .- 1437-4315. ; 399:9, s. 1099-1105
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of alpha 5/beta 1/alpha v/beta 3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- E-cadherin
- integrins
- kallikrein-related peptidase 7
- MCAM/CD146
- melanoma
- spheroid
Publication and Content Type
- ref (subject category)
- art (subject category)
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