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The enlarged popula...
The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.
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- Rolf, Julia (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Motta, Vinicius (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Duarte, Nadia (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Lundholm, Marie (author)
- Umeå universitet,Medicinsk och klinisk genetik
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- Berntman, Emma (author)
- Lund University,Lunds universitet,Umeå universitet,Medicinsk och klinisk genetik,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Bergman, Marie-Louise (author)
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- Sorokin, Lydia (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Cardell, Susanna (author)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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- Holmberg, Dan (author)
- Umeå universitet,Medicinsk och klinisk genetik
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(creator_code:org_t)
- 2005
- 2005
- English.
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In: Journal of Immunology. - 0022-1767 .- 1550-6606. ; 174:8, s. 4821-4827
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Abstract
Subject headings
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- The NOD mouse is an important experimental model for human type 1 diabetes. T cells are central to NOD pathogenesis, and their function in the autoimmune process of diabetes has been well studied. In contrast, although recognized as important players in disease induction, the role of B cells is not clearly understood. In this study we characterize different subpopulations of B cells and demonstrate that marginal zone (MZ) B cells are expanded 2- to 3-fold in NOD mice compared with nondiabetic C57BL/6 (B6) mice. The NOD MZ B cells displayed a normal surface marker profile and localized to the MZ region in the NOD spleen. Moreover, the MZ B cell population developed early during the ontogeny of NOD mice. By 3 wk of age, around the time when autoreactive T cells are first activated, a significant MZ B cell population of adult phenotype was found in NOD, but not B6, mice. Using an F2(B6 x NOD) cross in a genome-wide scan, we map the control of this trait to a region on chromosome 4 (logarithm of odds score, 4.4) which includes the Idd11 and Idd9 diabetes susceptibility loci, supporting the hypothesis that this B cell trait is related to the development of diabetes in the NOD mouse.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Age Factors
- Animals
- Antigens; CD1/*metabolism
- B-Lymphocyte Subsets/*immunology/pathology
- Chromosome Mapping
- Diabetes Mellitus; Type 1/*genetics/*immunology/pathology
- Female
- Humans
- Male
- Mice
- Mice; Inbred C57BL
- Mice; Inbred NOD/*genetics/*immunology
- Phenotype
- Spleen/immunology/pathology
- T-Lymphocytes/immunology
Publication and Content Type
- ref (subject category)
- art (subject category)
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