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Sökning: onr:"swepub:oai:DiVA.org:umu-152928" > Identifying a neuro...

  • de Pierrefeu, AmicieNeuroSpin, CEA, Gif-sur-Yvette, France (författare)

Identifying a neuroanatomical signature of schizophrenia, reproducible across sites and stages, using machine-learning with structured sparsity

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018-09-21
  • John Wiley & Sons,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-152928
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152928URI
  • https://doi.org/10.1111/acps.12964DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • ObjectiveStructural MRI (sMRI) increasingly offers insight into abnormalities inherent to schizophrenia. Previous machine learning applications suggest that individual classification is feasible and reliable and, however, is focused on the predictive performance of the clinical status in cross‐sectional designs, which has limited biological perspectives. Moreover, most studies depend on relatively small cohorts or single recruiting site. Finally, no study controlled for disease stage or medication's effect. These elements cast doubt on previous findings’ reproducibility.MethodWe propose a machine learning algorithm that provides an interpretable brain signature. Using large datasets collected from 4 sites (276 schizophrenia patients, 330 controls), we assessed cross‐site prediction reproducibility and associated predictive signature. For the first time, we evaluated the predictive signature regarding medication and illness duration using an independent dataset of first‐episode patients.ResultsMachine learning classifiers based on neuroanatomical features yield significant intersite prediction accuracies (72%) together with an excellent predictive signature stability. This signature provides a neural score significantly correlated with symptom severity and the extent of cognitive impairments. Moreover, this signature demonstrates its efficiency on first‐episode psychosis patients (73% accuracy).ConclusionThese results highlight the existence of a common neuroanatomical signature for schizophrenia, shared by a majority of patients even from an early stage of the disorder.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Löfstedt, TommyUmeå universitet,Radiofysik(Swepub:umu)toklot02 (författare)
  • Laidi, C.NeuroSpin, CEA, Gif-sur-Yvette, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France; Fondation Fondamental, Créteil, France; Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté, de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France (författare)
  • Hadj-Selem, FouadEnergy Transition Institute: VeDeCoM, Versailles, France (författare)
  • Bourgin, JulieDepartment of Psychiatry, Louis-Mourier Hospital, AP-HP, Colombes, France; INSERM U894, Centre for Psychiatry and Neurosciences, Paris, France (författare)
  • Hajek, TomasDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada; National Institute of Mental Health, Klecany, Czech Republic (författare)
  • Spaniel, FilipNational Institute of Mental Health, Klecany, Czech Republic (författare)
  • Kolenic, MarianNational Institute of Mental Health, Klecany, Czech Republic (författare)
  • Ciuciu, PhilippeNeuroSpin, CEA, Gif-sur-Yvette, France; INRIA, CEA, Parietal team, University of Paris-Saclay, France (författare)
  • Hamdani, NoraInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France; Fondation Fondamental, Créteil, France; Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté, de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France (författare)
  • Leboyer, MarionInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France; Fondation Fondamental, Créteil, France; Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté, de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France (författare)
  • Fovet, ThomasLaboratoire de Sciences Cognitives et Sciences Affectives (SCALab-PsyCHIC), CNRS UMR 9193, University of Lille; Pôle de Psychiatrie, Unité CURE, CHU Lille, Lille, France (författare)
  • Jardri, RenaudINRIA, CEA, Parietal team, University of Paris-Saclay, France; Laboratoire de Sciences Cognitives et Sciences Affectives (SCALab-PsyCHIC), CNRS UMR 9193, University of Lille; Pôle de Psychiatrie, Unité CURE, CHU Lille, Lille, France (författare)
  • Houenou, JosselinNeuroSpin, CEA, Gif-sur-Yvette, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle, Créteil, France; Fondation Fondamental, Créteil, France; Pôle de Psychiatrie, Assistance Publique–Hôpitaux de Paris (AP-HP), Faculté, de Médecine de Créteil, DHU PePsy, Hôpitaux Universitaires Mondor, Créteil, France (författare)
  • Duchesnay, EdouardNeuroSpin, CEA, Gif-sur-Yvette, France (författare)
  • NeuroSpin, CEA, Gif-sur-Yvette, FranceRadiofysik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta Psychiatrica Scandinavica: John Wiley & Sons138, s. 571-5800001-690X1600-0447

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