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Copy number variati...
Copy number variation : A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
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- Gu, Xiaolian, 1976- (author)
- Umeå universitet,Patologi
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Coates, Philip J. (author)
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- Boldrup, Linda (author)
- Umeå universitet,Patologi
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- Wang, Lixiao, 1975- (author)
- Umeå universitet,Patologi
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Krejci, Adam (author)
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Hupp, Ted (author)
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- Fåhraeus, Robin (author)
- Umeå universitet,Patologi,RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic; Institute of Molecular Genetics, University Paris 7, St. Louis Hospital, Paris, France
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- Norberg-Spaak, Lena (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Sgaramella, Nicola (author)
- Umeå universitet,Patologi
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- Wilms, Torben (author)
- Umeå universitet,Öron- näs- och halssjukdomar
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- Nylander, Karin (author)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2018-11-02
- 2019
- English.
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In: Journal of Oral Pathology & Medicine. - : John Wiley & Sons. - 0904-2512 .- 1600-0714. ; 48:1, s. 24-30
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Abstract
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- Background The incidence of squamous cell carcinoma of the oral tongue (SCCOT) is increasing in people under age 40. There is an urgent need to identify prognostic markers that help identify young SCCOT patients with poor prognosis in order to select these for individualized treatment. Materials and methods To identify genetic markers that can serve as prognostic markers for young SCCOT patients, we first investigated four young (<= 40 years) and five elderly patients (>= 50 years) using global RNA sequencing and whole-exome sequencing. Next, we combined our data with data on SCCOT from the cancer genome atlas (TCGA), giving a total of 16 young and 104 elderly, to explore the correlations between genomic variations and clinical outcomes. Results In agreement with previous studies, we found that SCCOT from young and elderly patients was transcriptomically and also genomically similar with no significant differences regarding cancer driver genes, germline predisposition genes, or the burden of somatic single nucleotide variations (SNVs). However, a disparate copy number variation (CNV) was found in young patients with distinct clinical outcome. Combined with data from TCGA, we found that the overall survival was significantly better in young patients with low-CNV (n = 5) compared to high-CNV (n = 11) burden (P = 0.044). Conclusions Copy number variation burden is a useful single prognostic marker for SCCOT from young, but not elderly, patients. CNV burden thus holds promise to form an important contribution when selecting suitable treatment protocols for young patients with SCCOT.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- age
- copy number variation
- prognosis
- squamous cell carcinoma of the oral tongue
- whole-exome sequencing
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gu, Xiaolian, 19 ...
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Coates, Philip J ...
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Boldrup, Linda
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Wang, Lixiao, 19 ...
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Krejci, Adam
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Hupp, Ted
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show more...
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Fåhraeus, Robin
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Norberg-Spaak, L ...
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Sgaramella, Nico ...
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Wilms, Torben
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Nylander, Karin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Oral ...
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Umeå University