Sökning: onr:"swepub:oai:DiVA.org:umu-158366" > Association between...
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000 | 06649naa a2201033 4500 | |
001 | oai:DiVA.org:umu-158366 | |
003 | SwePub | |
008 | 190429s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:140666794 | |
009 | oai:lup.lub.lu.se:3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1583662 URI |
024 | 7 | a https://doi.org/10.1016/j.jhep.2018.12.0142 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1406667942 URI |
024 | 7 | a https://lup.lub.lu.se/record/3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b2 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Baumeister, Sebastian E.u Ludwig-Maximilian University of Munich,University Medicine Greifswald4 aut |
245 | 1 0 | a Association between physical activity and risk of hepatobiliary cancers :b A multinational cohort study |
264 | 1 | b Elsevier BV,c 2019 |
338 | a print2 rdacarrier | |
520 | a Background & Aims: To date, evidence on the association between physical activity and risk of hepatobiliary cancers has been inconclusive. We examined this association in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).Methods: We identified 275 hepatocellular carcinoma (HCC) cases, 93 intrahepatic bile duct cancers (IHBCs), and 164 non-gallbladder extrahepatic bile duct cancers (NGBCs) among 467,336 EPIC participants (median follow-up 14.9 years). We estimated cause-specific hazard ratios (HRs) for total physical activity and vigorous physical activity and performed mediation analysis and secondary analyses to assess robustness to confounding (e.g. due to hepatitis virus infection).Results: In the EPIC cohort, the multivariable-adjusted HR of HCC was 0.55 (95% CI 0.38–0.80) comparing active and inactive individuals. Regarding vigorous physical activity, for those reporting >2 hours/week compared to those with no vigorous activity, the HR for HCC was 0.50 (95% CI 0.33–0.76). Estimates were similar in sensitivity analyses for confounding. Total and vigorous physical activity were unrelated to IHBC and NGBC. In mediation analysis, waist circumference explained about 40% and body mass index 30% of the overall association of total physical activity and HCC.Conclusions: These findings suggest an inverse association between physical activity and risk of HCC, which is potentially mediated by obesity.Lay summary: In a pan-European study of 467,336 men and women, we found that physical activity is associated with a reduced risk of developing liver cancers over the next decade. This risk was independent of other liver cancer risk factors, and did not vary by age, gender, smoking status, body weight, and alcohol consumption. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Hepatobiliary cancer | |
653 | a Hepatocellular carcinoma | |
653 | a Liver cancer | |
653 | a Physical activity | |
653 | a Hepatobiliary cancer | |
653 | a Hepatocellular carcinoma | |
653 | a Liver cancer | |
653 | a Physical activity | |
700 | 1 | a Schlesinger, Sabrina4 aut |
700 | 1 | a Aleksandrova, Krasimira4 aut |
700 | 1 | a Jochem, Carmen4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Gunter, Marc J.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Carbonnel, Franck4 aut |
700 | 1 | a Fournier, Agnes4 aut |
700 | 1 | a Kuehn, Tilman4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Pischon, Tobias4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Bamia, Christina4 aut |
700 | 1 | a La Vecchia, Carlo4 aut |
700 | 1 | a Masala, Giovanna4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Fasanelli, Francescau University of Regensburg4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Grioni, Sara4 aut |
700 | 1 | a de Mesquita, Bas Bueno4 aut |
700 | 1 | a Vermeulen, Roel4 aut |
700 | 1 | a May, Anne M.4 aut |
700 | 1 | a Borch, Kristin B.4 aut |
700 | 1 | a Oyeyemi, Sunday O.4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Rodriguez-Barranco, Miguel4 aut |
700 | 1 | a Chirlaque Lopez, Maria Dolores4 aut |
700 | 1 | a Felez-Nobrega, Mireia4 aut |
700 | 1 | a Sonestedt, Emilyu Lund University,Lunds universitet,Nutritionsepidemiologi,Forskargrupper vid Lunds universitet,Nutrition Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-eso |
700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-boh |
700 | 1 | a Hemmingsson, Oskar,d 1975-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)osrhen96 |
700 | 1 | a Werner, Mårtenu Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)manwer04 |
700 | 1 | a Perez-Cornago, Aurora4 aut |
700 | 1 | a Ferrari, Pietro4 aut |
700 | 1 | a Stepien, Magdalena4 aut |
700 | 1 | a Freisling, Heinz4 aut |
700 | 1 | a Tsilidis, Konstantinos K.4 aut |
700 | 1 | a Ward, Heather4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Weiderpass, Elisabeteu Karolinska Institutet4 aut |
700 | 1 | a Leitzmann, Michael F.4 aut |
710 | 2 | a Ludwig-Maximilian University of Munichb University Medicine Greifswald4 org |
710 | 2 | a et al. |
773 | 0 | t Journal of Hepatologyd : Elsevier BVg 70:5, s. 885-892q 70:5<885-892x 0168-8278x 1600-0641 |
856 | 4 | u http://dspace.library.uu.nl/bitstream/1874/385064/1/Association_betrween_physical_activity.pdf |
856 | 4 | u http://dx.doi.org/10.1016/j.jhep.2018.12.014y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158366 |
856 | 4 8 | u https://doi.org/10.1016/j.jhep.2018.12.014 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:140666794 |
856 | 4 8 | u https://lup.lub.lu.se/record/3cdc1f4c-aa54-4b58-8652-d5a9ddc5132b |
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