Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

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Fältnamn	Indikatorer	Metadata
000		05283naa a2200973 4500
001		oai:DiVA.org:umu-160609
003		SwePub
008		190624s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1606092 URI
024	7	a https://doi.org/10.1038/s41586-019-1237-92 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lloyd-Price, Jason4 aut
245	1 0	a Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases
264		c 2019-05-29
264	1	b Nature Publishing Group,c 2019
338		a print2 rdacarrier
520		a Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect several million individuals worldwide. Crohn's disease and ulcerative colitis are complex diseases that are heterogeneous at the clinical, immunological, molecular, genetic, and microbial levels. Individual contributing factors have been the focus of extensive research. As part of the Integrative Human Microbiome Project (HMP2 or iHMP), we followed 132 subjects for one year each to generate integrated longitudinal molecular profiles of host and microbial activity during disease (up to 24 time points each; in total 2,965 stool, biopsy, and blood specimens). Here we present the results, which provide a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease activity. We demonstrate a characteristic increase in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in microbial transcription (for example, among clostridia), metabolite pools (acylcarnitines, bile acids, and short-chain fatty acids), and levels of antibodies in host serum. Periods of disease activity were also marked by increases in temporal variability, with characteristic taxonomic, functional, and biochemical shifts. Finally, integrative analysis identified microbial, biochemical, and host factors central to this dysregulation. The study's infrastructure resources, results, and data, which are available through the Inflammatory Bowel Disease Multi'omics Database (http://ibdmdb.org), provide the most comprehensive description to date of host and microbial activities in inflammatory bowel diseases.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
700	1	a Arze, Cesar4 aut
700	1	a Ananthakrishnan, Ashwin N.4 aut
700	1	a Schirmer, Melanie4 aut
700	1	a Avila-Pacheco, Julian4 aut
700	1	a Poon, Tiffany W.4 aut
700	1	a Andrews, Elizabeth4 aut
700	1	a Ajami, Nadim J.4 aut
700	1	a Bonham, Kevin S.4 aut
700	1	a Brislawn, Colin J.4 aut
700	1	a Casero, David4 aut
700	1	a Courtney, Holly4 aut
700	1	a Gonzalez, Antonio4 aut
700	1	a Graeber, Thomas G.4 aut
700	1	a Hall, A. Brantley4 aut
700	1	a Lake, Kathleen4 aut
700	1	a Landers, Carol J.4 aut
700	1	a Mallick, Himel4 aut
700	1	a Plichta, Damian R.4 aut
700	1	a Prasad, Mahadev4 aut
700	1	a Rahnavard, Gholamali4 aut
700	1	a Sauk, Jenny4 aut
700	1	a Shungin, Dmitryu Umeå universitet,Institutionen för odontologi,Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA4 aut0 (Swepub:umu)dmsh0003
700	1	a Vazquez-Baeza, Yoshiki4 aut
700	1	a White, Richard A., III4 aut
700	1	a Braun, Jonathan4 aut
700	1	a Denson, Lee A.4 aut
700	1	a Jansson, Janet K.4 aut
700	1	a Knight, Rob4 aut
700	1	a Kugathasan, Subra4 aut
700	1	a McGovern, Dermot P. B.4 aut
700	1	a Petrosino, Joseph F.4 aut
700	1	a Stappenbeck, Thaddeus S.4 aut
700	1	a Winter, Harland S.4 aut
700	1	a Clish, Clary B.4 aut
700	1	a Franzosa, Eric A.4 aut
700	1	a Vlamakis, Hera4 aut
700	1	a Xavier, Ramnik J.4 aut
700	1	a Huttenhower, Curtis4 aut
700	1	a Bishai, Jason4 aut
700	1	a Bullock, Kevin4 aut
700	1	a Deik, Amy4 aut
700	1	a Dennis, Courtney4 aut
700	1	a Kaplan, Jess L.4 aut
700	1	a Khalili, Hamed4 aut
700	1	a McIver, Lauren J.4 aut
700	1	a Moran, Christopher J.4 aut
700	1	a Nguyen, Long4 aut
700	1	a Pierce, Kerry A.4 aut
700	1	a Schwager, Randall4 aut
700	1	a Sirota-Madi, Alexandra4 aut
700	1	a Stevens, Betsy W.4 aut
700	1	a Tan, William4 aut
700	1	a ten Hoeve, Johanna J.4 aut
700	1	a Weingart, George4 aut
700	1	a Wilson, Robin G.4 aut
700	1	a Yajnik, Vijay4 aut
710	2	a Umeå universitetb Institutionen för odontologi4 org
773	0	t Natured : Nature Publishing Groupg 569:7758, s. 655-661q 569:7758<655-661x 0028-0836x 1476-4687
856	4	u https://www.nature.com/articles/s41586-019-1237-9.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160609
856	4 8	u https://doi.org/10.1038/s41586-019-1237-9

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Av författaren/redakt...: Lloyd-Price, Jas ...; Arze, Cesar; Ananthakrishnan, ...; Schirmer, Melani ...; Avila-Pacheco, J ...; Poon, Tiffany W.; visa fler...; Andrews, Elizabe ...; Ajami, Nadim J.; Bonham, Kevin S.; Brislawn, Colin ...; Casero, David; Courtney, Holly; Gonzalez, Antoni ...; Graeber, Thomas ...; Hall, A. Brantle ...; Lake, Kathleen; Landers, Carol J ...; Mallick, Himel; Plichta, Damian ...; Prasad, Mahadev; Rahnavard, Ghola ...; Sauk, Jenny; Shungin, Dmitry; Vazquez-Baeza, Y ...; White, Richard A ...; Braun, Jonathan; Denson, Lee A.; Jansson, Janet K ...; Knight, Rob; Kugathasan, Subr ...; McGovern, Dermot ...; Petrosino, Josep ...; Stappenbeck, Tha ...; Winter, Harland ...; Clish, Clary B.; Franzosa, Eric A ...; Vlamakis, Hera; Xavier, Ramnik J ...; Huttenhower, Cur ...; Bishai, Jason; Bullock, Kevin; Deik, Amy; Dennis, Courtney; Kaplan, Jess L.; Khalili, Hamed; McIver, Lauren J ...; Moran, Christoph ...; Nguyen, Long; Pierce, Kerry A.; Schwager, Randal ...; Sirota-Madi, Ale ...; Stevens, Betsy W ...; Tan, William; ten Hoeve, Johan ...; Weingart, George; Wilson, Robin G.; Yajnik, Vijay; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Gastroenterologi

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Av lärosätet: Umeå universitet

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