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Herpes Simplex Viru...
Herpes Simplex Virus, APOE ɛ4, and Cognitive Decline in Old Age : Results from the Betula Cohort Study
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden
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- Norman, Tove (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden
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- Weidung, Bodil (author)
- Uppsala universitet,Umeå universitet,Geriatrik,Department of Public Health and Caring Sciences, Geriatric Medicine, Uppsala University, Sweden,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden
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- Olsson, Jan (author)
- Umeå universitet,Avdelningen för virologi,Umeå Univ, Dept Clin Microbiol, Virol, Umeå, Sweden
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- Josefsson, Maria, 1979- (author)
- Umeå universitet,Enheten för demografi och åldrandeforskning (CEDAR),Umeå centrum för funktionell hjärnavbildning (UFBI),Umeå Univ, Ctr Demog & Ageing Res, Umeå, Sweden; Umeå Univ, Umeci Ctr Funct Brain Imaging, Umeå, Sweden
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- Adolfsson, Rolf (author)
- Umeå universitet,Psykiatri,Umeå Univ, Dept Clin Sci, Psychiat, Umeå, Sweden
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),Umeå Univ, Umeci Ctr Funct Brain Imaging, Umeå, Sweden; Umeå Univ, Dept Radiat Sci, Umeå, Sweden; Umeå Univ, Dept Integrat Med Biol, Umeå, Sweden
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Avdelningen för virologi,Umeå Univ, Dept Clin Microbiol, Virol, Umeå, Sweden
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(creator_code:org_t)
- IOS Press, 2019
- 2019
- English.
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In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 67:1, s. 211-220
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Background: Herpes simplex virus (HSV) has been suggested to play a role in Alzheimer’s disease (AD) development.Objective: The aim of the present study was to investigate the early AD-related symptom episodic memory decline in relation to HSV and carriage of allele 4 of the apolipoprotein E gene (APOE ɛ4) in a large population-based cohort with a long follow-up time.Methods: The study included 3,413 persons, with longitudinal data available for 1,293 persons with a mean follow-up time of 11.6 years. The associations between HSV carriage, APOE ɛ4 carriage, and episodic memory was investigated at baseline, as well as in longitudinal analyses where individuals with and without HSV antibodies (HSV1/2 non-specific) were matched and episodic memory decline compared.Results: Cross-sectional analyses revealed an age-dependent association of HSV carriage with lower episodic memory function, particularly among APOE ɛ4 carriers (p = 0.008). Longitudinal analyses showed an increased risk of episodic memory decline in HSV carriers (≥65 years: p < 0.001, all ages: non-significant), and a significant interaction between HSV and APOE ɛ4 for episodic memory decline (p < 0.001).Conclusion: In this large population-based cohort study, both cross-sectional and longitudinal results support an association between HSV carriage and declining episodic memory function, especially among APOE ɛ4 carriers. The results strengthen the hypothesis that HSV is associated with AD development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Alzheimer’s disease
- APOE ɛ4
- apolipoprotein E4
- cognitive impairment
- cohort study
- dementia
- epidemiological study
- episodic memory
- herpes simplex virus
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lövheim, Hugo, 1 ...
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Norman, Tove
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Weidung, Bodil
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Olsson, Jan
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Josefsson, Maria ...
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Adolfsson, Rolf
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Nyberg, Lars, 19 ...
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Elgh, Fredrik, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Journal of Alzhe ...
- By the university
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Umeå University
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Uppsala University