Sökning: onr:"swepub:oai:DiVA.org:umu-164387" > Morning plasma cort...
Fältnamn | Indikatorer | Metadata |
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000 | 03853naa a2200445 4500 | |
001 | oai:DiVA.org:umu-164387 | |
003 | SwePub | |
008 | 191112s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1643872 URI |
024 | 7 | a https://doi.org/10.1530/EJE-19-01612 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Crawford, Andrew A.4 aut |
245 | 1 0 | a Morning plasma cortisol as a cardiovascular risk factor :b findings from prospective cohort and Mendelian randomization studies |
264 | 1 | b Bioscientifica,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Objective: The identification of new causal risk factors has the potential to improve cardiovascular disease (CVD) risk prediction and the development of new treatments to reduce CVD deaths. In the general population, we sought to determine whether cortisol is a causal risk factor for CVD and coronary heart disease (CHD).Design and methods: Three approaches were adopted to investigate the association between cortisol and CVD/CHD. First, we used multivariable regression in two prospective nested case-control studies (total 798 participants, 313 incident CVD/CHD with complete data). Second, a random-effects meta-analysis of these data and previously published prospective associations was performed (total 6680 controls, 696 incident CVD/CHD). Finally, one- and two-sample Mendelian randomization analyses were performed (122,737 CHD cases, 547,261 controls for two-sample analyses).Results: In the two prospective nested case-control studies, logistic regression adjusting for sex, age, BMI, smoking and time of sampling, demonstrated a positive association between morning plasma cortisol and incident CVD (OR: 1.28 per 1 SD higher cortisol, 95% CI: 1.06-1.54). In the meta-analysis of prospective studies, the equivalent result was OR: 1.18, 95% CI: 1.06-1.31. Results from the two-sample Mendelian randomization were consistent with these positive associations: OR: 1.06, 95% Cl: 0.98-1.15.Conclusions: All three approaches demonstrated a positive association between morning plasma cortisol and incident CVD. Together, these findings suggest that elevated morning cortisol is a causal risk factor for CVD. The current data suggest strategies targeted at lowering cortisol action should be evaluated for their effects on CVD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001 |
700 | 1 | a Kirschbaum, Clemens4 aut |
700 | 1 | a Murphy, Lee4 aut |
700 | 1 | a Eliasson, Matsu Umeå universitet,Avdelningen för medicin,Sunderby Research Unit, Umeå University, Umeå, Sweden4 aut0 (Swepub:umu)mael0021 |
700 | 1 | a Ebrahim, Shah4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a Olsson, Tommyu Umeå universitet,Avdelningen för medicin4 aut0 (Swepub:umu)tool0003 |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Lawlor, Debbie A.4 aut |
700 | 1 | a Timpson, Nicolas J.4 aut |
700 | 1 | a Reynolds, Rebecca M.4 aut |
700 | 1 | a Walker, Brian R.4 aut |
710 | 2 | a Umeå universitetb Kardiologi4 org |
773 | 0 | t European Journal of Endocrinologyd : Bioscientificag 181:4, s. 429-438q 181:4<429-438x 0804-4643x 1479-683X |
856 | 4 | u https://doi.org/10.1530/EJE-19-0161y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1369538/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164387 |
856 | 4 8 | u https://doi.org/10.1530/EJE-19-0161 |
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