Sökning: onr:"swepub:oai:DiVA.org:umu-187436" > Tumor-Educated Plat...
Fältnamn | Indikatorer | Metadata |
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000 | 03807naa a2200661 4500 | |
001 | oai:DiVA.org:umu-187436 | |
003 | SwePub | |
008 | 210910s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1874362 URI |
024 | 7 | a https://doi.org/10.1016/j.xcrm.2020.1001012 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Sol, Nik4 aut |
245 | 1 0 | a Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma |
264 | 1 | b Elsevier,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor glioblastoma. We assessed specificity by comparing the spliced RNA profile of TEPs from glioblastoma patients with multiple sclerosis and brain metastasis patients (validation series, n = 157; accuracy, 80%; AUC, 0.81 [95% CI, 0.74-0.89; p < 0.001]). Second, analysis of patients with glioblastoma versus asymptomatic healthy controls in an independent validation series (n = 347) provided a detection accuracy of 95% and AUC of 0.97 (95% CI, 0.95-0.99; p < 0.001). Finally, we developed the digitalSWARM algorithm to improve monitoring of glioblastoma progression and demonstrate that the TEP tumor scores of individual glioblastoma patients represent tumor behavior and could be used to distinguish false positive progression from true progression (validation series, n = 20; accuracy, 85%; AUC, 0.86 [95% CI, 0.70-1.00; p < 0.012]). In conclusion, TEPs have potential as a minimally invasive biosource for blood-based diagnostics and monitoring of glioblastoma patients. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a 't Veld, Sjors G. J. G. in4 aut |
700 | 1 | a Vancura, Adrienne4 aut |
700 | 1 | a Tjerkstra, Maud4 aut |
700 | 1 | a Leurs, Cyra4 aut |
700 | 1 | a Rustenburg, Francois4 aut |
700 | 1 | a Schellen, Pepijn4 aut |
700 | 1 | a Verschueren, Heleen4 aut |
700 | 1 | a Post, Edward4 aut |
700 | 1 | a Zwaan, Kenn4 aut |
700 | 1 | a Ramaker, Jip4 aut |
700 | 1 | a Wedekind, Laurine E.4 aut |
700 | 1 | a Tannous, Jihane4 aut |
700 | 1 | a Ylstra, Bauke4 aut |
700 | 1 | a Killestein, Joep4 aut |
700 | 1 | a Mateen, Farrah4 aut |
700 | 1 | a Idema, Sander4 aut |
700 | 1 | a Hamer, Philip C. de Witt4 aut |
700 | 1 | a Navis, Anna C.4 aut |
700 | 1 | a Leenders, William P. J.4 aut |
700 | 1 | a Hoeben, Ann4 aut |
700 | 1 | a Moraal, Bastiaan4 aut |
700 | 1 | a Noske, David P.4 aut |
700 | 1 | a Vandertop, W. Peter4 aut |
700 | 1 | a Nilsson, R. Jonas A.u Umeå universitet,Onkologi,Department of Neurosurgery, Cancer Center Amsterdam, University Medical Center, Amsterdam, the Netherlands4 aut0 (Swepub:umu)joni0002 |
700 | 1 | a Tannous, Bakhos A.4 aut |
700 | 1 | a Wesseling, Pieter4 aut |
700 | 1 | a Reijneveld, Jaap C.4 aut |
700 | 1 | a Best, Myron G.4 aut |
700 | 1 | a Wurdinger, Thomas4 aut |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t Cell Reports Medicined : Elsevierg 1:7q 1:7x 2666-3791 |
856 | 4 | u https://doi.org/10.1016/j.xcrm.2020.100101y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1593021/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.cell.com/article/S2666379120301270/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-187436 |
856 | 4 8 | u https://doi.org/10.1016/j.xcrm.2020.100101 |
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