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Aggregatibacter act...
Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus in a Kenyan Maasai Adolescent Population and Inhibition of Leukotoxic Activity by Herbal Plants Used as Part of Oral Hygiene Procedures
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- Lindholm, Mark (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen
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- Claesson, Rolf (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen
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- Kemoli, Arthur (författare)
- Department of Paediatric Dentistry & Orthodontics, University of Nairobi, Nairobi, Kenya
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- Mulli, Tonnie (författare)
- Department of Periodontology, University of Nairobi, Nairobi, Kenya
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- Oscarsson, Jan (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen
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- Haubek, Dorte (författare)
- Department of Dentistry and Oral Health, Health, Aarhus University, Aarhus, Denmark
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- Johansson, Anders, 1955- (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen
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(creator_code:org_t)
- 2021-11-19
- 2021
- Engelska.
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Ingår i: Journal of Clinical Medicine. - Basel : MDPI. - 2077-0383. ; 10:22
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- BACKGROUND: A virulent genotype (JP2) of the periodonto-pathogen, Aggregatibacter actinomycetemcomitans (Aa), is widespread in North and West Africa, while its presence in East Africa has not been thoroughly investigated. This JP2 genotype is associated with periodontitis in adolescents and has a high leukotoxicity. The aim of the study was to examine the prevalence of Aa and its JP2 genotype, the prevalence of the oral, commensal Aggregatibacter aphrophilus in a Maasai adolescent population, and the effect of herbal plants for inhibition of leukotoxicity.METHODS: A total of 284 adolescents from Maasai Mara, Kenya, underwent an oral examination and microbial sampling. The presence of Aa and A. aphrophilus was analyzed by quantitative PCR and cultivation (the 58 samples collected at the last day of field study). The collected Aa strains were characterized and leukotoxin promoter typed. Additionally, herbal plants commonly used for oral hygiene were assessed for the inhibition of leukotoxicity.RESULTS AND CONCLUSIONS: The prevalence of Aa in stimulated whole saliva was high (71.8%), with the JP2 genotype detected in one individual, and A. aphrophilus in 99% of the sampled individuals. The commonly used herbal plant, Warburgia ugandensis, inactivated Aa leukotoxicity. The Aa virulence might be reduced through use of W. ugandensis and the high levels of A. aphrophilus.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Aggregatibacter actinomycetemcomitans
- Aggregatibacter aphrophilus
- Maasai adolescents
- herbal plants
- leukotoxicity
- odontologi
- Odontology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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