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Effects of toxic li...
Effects of toxic lithium levels on ECG : findings from the LiSIE retrospective cohort study
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- Truedson, Petra (författare)
- Umeå universitet,Psykiatri
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- Ott, Michael (författare)
- Umeå universitet,Avdelningen för medicin
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- Lindmark, Krister (författare)
- Karolinska Institutet,Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden
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- Ström, Malin (författare)
- Department of Psychiatry, Sunderby Hospital, Luleå, Sweden
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- Maripuu, Martin (författare)
- Umeå universitet,Psykiatri
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- Lundqvist, Robert (författare)
- Umeå universitet,Avdelningen för medicin
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- Werneke, Ursula (författare)
- Umeå universitet,Psykiatri
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(creator_code:org_t)
- 2022-10-08
- 2022
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 11:19
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- (1) Background: Few studies have explored the impact of lithium intoxication on the heart.(2) Methods: We examined electrocardiogram (ECG) changes associated with lithium intoxication in the framework of the LiSIE (Lithium-Study into Effects and Side Effects) retrospective cohort study. We analysed ECGs before, during, and after intoxication.(3) Results: Of the 1136 patients included, 92 patients had experienced 112 episodes of lithium intoxication. For 55 episodes, there was an ECG available at the time; for 48 episodes, there was a reference ECG available before and/or after the lithium intoxication. Lithium intoxication led to a statistically significant decrease in heart rate from a mean 76 beats/min (SD 16.6) before intoxication to 73 beats/min (SD 17.1) during intoxication (p = 0.046). QTc correlated only weakly with lithium concentration (ρ = 0.329, p = 0.014). However, in 24% of lithium intoxication episodes, there were QT prolongations. In 54% of these, QTc exceeded 500 ms; patients with chronic intoxications being more affected.(4) Conclusions: Based on summary statistics, effects of lithium intoxication on HR and QTc seem mostly discrete and not clinically relevant. However, QT prolongation can carry a risk of becoming severe. Therefore, an ECG should always be taken in patients presenting with lithium intoxication.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- lithium
- drug-related side effects and adverse reactions
- toxicity
- long QT syndrome
- electrocardiography
- Medicine
- medicin
- kardiologi
- Cardiology
- psykiatri
- Psychiatry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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