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Phenotypic characte...
Phenotypic characterization of patient dengue virus isolates in BALB/c mice differentiates dengue fever and dengue hemorrhagic fever from dengue shock syndrome
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- Tuiskunen, Anne (author)
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Swedish Institute for Communicable Disease Control, Solna, Sweden; Virology Department, French Army Forces Biomedical Institute (IRBA), Marseille, France
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Wahlström, Maria (author)
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Bergström, Jakob (author)
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Buchy, Philippe (author)
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Leparc-Goffart, Isabelle (author)
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Lundkvist, Åke (author)
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(creator_code:org_t)
- 2011-08-11
- 2011
- English.
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In: Virology Journal. - : BioMed Central (BMC). - 1743-422X. ; 8:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://virologyj.bi...
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Abstract
Subject headings
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- Dengue virus (DENV) infection is the most common arthropod-borne viral disease in man and there are approximately 100 million infections annually. Despite the global burden of DENV infections many important questions regarding DENV pathogenesis remain unaddressed due to the lack of appropriate animal models of infection and disease. A major problem is the fact that no non-human species naturally develop disease similar to human dengue fever (DF) or dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Apart from other risk factors for severe dengue such as host genetics and secondary infection with a heterologous DENV, virus virulence is a risk factor that is not well characterized.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- : dengue virus
- mouse model
- tropism
- clinical isolate
- cytokines
- dengue hemorrhagic fever
- flavivirus
Publication and Content Type
- ref (subject category)
- art (subject category)
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