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Selection against P...
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
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Garrison, Sean P (author)
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Jeffers, John R (author)
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Yang, Chunying (author)
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- Nilsson, Jonas A (author)
- Umeå universitet,Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Nilsson
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Hall, Mark A (author)
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Rehg, Jerold E (author)
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Yue, Wen (author)
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Yu, Jian (author)
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Zhang, Lin (author)
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Onciu, Mihaela (author)
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Sample, Jeffery T (author)
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Cleveland, John L (author)
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Zambetti, Gerard P (author)
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(creator_code:org_t)
- 2008
- 2008
- English.
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In: Molecular and cellular biology. - 1098-5549. ; 28:17, s. 5391-402
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40% of primary human Burkitt lymphomas fail to express detectable levels of PUMA and in some tumors this is associated with DNA methylation. Burkitt lymphoma cell lines phenocopy the primary tumors with respect to DNA methylation and diminished PUMA expression, which can be reactivated following inhibition of DNA methyltransferases. These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics.
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- By the author/editor
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Garrison, Sean P
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Jeffers, John R
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Yang, Chunying
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Nilsson, Jonas A
-
Hall, Mark A
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Rehg, Jerold E
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show more...
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Yue, Wen
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Yu, Jian
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Zhang, Lin
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Onciu, Mihaela
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Sample, Jeffery ...
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Cleveland, John ...
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Zambetti, Gerard ...
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show less...
- Articles in the publication
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Molecular and ce ...
- By the university
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Umeå University