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High plasma oxytoci...
High plasma oxytocin levels in men with hypersexual disorder
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- Flanagan, John (författare)
- Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Chatzittofis, Andreas (författare)
- Umeå universitet,Psykiatri,Medical School, University of Cyprus, Nicosia, Cyprus
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- Boström, Adrian Desai E. (författare)
- Umeå universitet,Psykiatri,Neuropaediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Hallberg, Jonas (författare)
- Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Öberg, Katarina Görts (författare)
- Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Arver, Stefan (författare)
- Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
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- Jokinen, Jussi (författare)
- Karolinska Institutet,Umeå universitet,Psykiatri,Department of Clinical Neuroscience/Psychiatry, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2022-02-02
- 2022
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 107:5, s. e1816-e1822
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Abstract
Ämnesord
Stäng
- Context: Hypersexual disorder (HD) involves excessive, persistent sexual behaviors related to various mood states and the diagnosis compulsive sexual behavior disorder is included as an impulse control disorder in the 11th revision of the International Classification of Diseases. Although the neurobiology behind the disorder is not clear, some studies suggest dysregulated hypothalamic-pituitary-adrenal axis. Oxytocin acts as counterregulatory neuroendocrine hormone to cortisol and is also involved in sexual behavior.Objective: We hypothesized that oxytocin may play a role in the pathophysiology of HD with compensatory actions to cortisol.Design: Longitudinal.Setting: ANOVA clinic (Karolinska University Hospital).Patients or other participants: 64 males with HD and 38 age-matched healthy volunteers.Main Outcome Measures: Plasma oxytocin levels, measured with radioimmunoassay; Hypersexual Disorder Screening Inventory; and Hypersexual Disorder: Current Assessment Scale for assessing hypersexual symptoms.Interventions: A patient subgroup (n=30) completed the manual-based group-administered cognitive-behavioral therapy (CBT) program for HD, and posttreatment oxytocin levels were measured.Results: Hypersexual men (n=64) exhibited significantly higher oxytocin plasma levels (mean±SD: 31.0±9.9 pM) compared with healthy volunteers (16.9±3.9 pM; P<0.001). There were significant positive correlations between oxytocin levels and the rating scales measuring hypersexual behavior. Patients who completed CBT treatment (n=30) had a significant reduction of oxytocin plasma levels from pretreatment (30.5±10.1 pM) to posttreatment (20.2±8.0 pM; P<0.001).Conclusions: The results suggest that the hyperactive oxytocinergic system in hypersexual men may be a compensatory mechanism to attenuate hyperactive stress.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- cognitive behavioral therapy
- compulsive sexual behavior disorder
- hypersexual disorder
- oxytocin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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