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Lung cancer risk di...
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Feng, XiaoshuangGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Oxford University Press,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-214407
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214407URI
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https://doi.org/10.1093/jnci/djad071DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.METHODS: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided.RESULTS: The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (Pdifference = .001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model.CONCLUSION: Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wu, Wendy Yi-YingUmeå universitet,Onkologi(Swepub:umu)weyi0002
(författare)
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Onwuka, Justina UcheojorGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Haider, ZahraUmeå universitet,Onkologi(Swepub:umu)zaha0008
(författare)
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Alcala, KarineGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Smith-Byrne, KarlCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
(författare)
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Zahed, HanaGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Guida, FlorenceEnvironment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Wang, RenweiDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
(författare)
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Bassett, Julie K.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia
(författare)
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Stevens, VictoriaRollins School of Public Health, Emory University, GA, Atlanta, United States
(författare)
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Wang, YingAmerican Cancer Society, GA, Atlanta, United States
(författare)
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Weinstein, StephanieMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
(författare)
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Freedman, Neal D.Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
(författare)
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Chen, ChuProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, WA, Seattle, United States
(författare)
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Tinker, LesleyWomen's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
(författare)
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Nøst, Therese HaugdahlDepartment of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway
(författare)
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Koh, Woon-PuayHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore
(författare)
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Muller, DavidDivision of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom
(författare)
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Colorado-Yohar, Sandra M.Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
(författare)
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Tumino, RosarioHyblean Association for Epidemiological Research, Ragusa, Italy
(författare)
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Hung, Rayjean J.Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
(författare)
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Amos, Christopher I.Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
(författare)
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Lin, XihongDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Statistics, Harvard University, MA, Cambridge, United States
(författare)
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Zhang, XuehongBrigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
(författare)
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Arslan, Alan A.Department of Population Health, New York University School of Medicine, New York, NY, USA
(författare)
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Sánchez, Maria-JoseCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ib, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
(författare)
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Sørgjerd, Elin PettersenHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
(författare)
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Severi, GianlucaInserm, Université Paris-Saclay, Villejuif, France
(författare)
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Hveem, KristianHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
(författare)
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Brennan, PaulGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Langhammer, ArnulfHUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
(författare)
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Milne, Roger L.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
(författare)
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Yuan, Jian-MinDivision of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
(författare)
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Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010
(författare)
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Johansson, MikaelUmeå universitet,Onkologi(Swepub:umu)mijo0025
(författare)
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Robbins, Hilary A.Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Johansson, MattiasGenomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
(författare)
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Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, FranceOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the National Cancer Institute: Oxford University Press115:9, s. 1050-10590027-88741460-2105
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Till lärosätets databas
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Feng, Xiaoshuang
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Wu, Wendy Yi-Yin ...
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Onwuka, Justina ...
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Haider, Zahra
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Alcala, Karine
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Smith-Byrne, Kar ...
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visa fler...
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Zahed, Hana
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Guida, Florence
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Wang, Renwei
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Bassett, Julie K ...
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Stevens, Victori ...
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Wang, Ying
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Weinstein, Steph ...
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Freedman, Neal D ...
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Chen, Chu
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Tinker, Lesley
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Nøst, Therese Ha ...
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Koh, Woon-Puay
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Muller, David
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Colorado-Yohar, ...
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Tumino, Rosario
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Hung, Rayjean J.
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Amos, Christophe ...
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Lin, Xihong
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Zhang, Xuehong
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Arslan, Alan A.
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Sánchez, Maria-J ...
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Sørgjerd, Elin P ...
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Severi, Gianluca
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Hveem, Kristian
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Brennan, Paul
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Langhammer, Arnu ...
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Milne, Roger L.
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Yuan, Jian-Min
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Melin, Beatrice ...
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Johansson, Mikae ...
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Robbins, Hilary ...
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Johansson, Matti ...
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