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Amphetamine-induced...
Amphetamine-induced dopamine release in rat : Whole-brain spatiotemporal analysis with [11C]raclopride and positron emission tomography
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- Johansson, Jarkko (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Diagnostisk radiologi
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- Ericsson, Madelene (författare)
- Umeå universitet,Umeå centrum för molekylär medicin (UCMM)
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- Axelsson, Jan, 1966- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Radiofysik
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- af Bjerkén, Sara (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Neurovetenskaper
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- Virel, Ana (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)
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- Karalija, Nina, 1984- (författare)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)
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(creator_code:org_t)
- Sage Publications, 2024
- 2024
- Engelska.
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Ingår i: Journal of Cerebral Blood Flow and Metabolism. - : Sage Publications. - 0271-678X .- 1559-7016. ; 44:3, s. 434-445
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Whole-brain mapping of drug effects are needed to understand the neural underpinnings of drug-related behaviors. Amphetamine administration is associated with robust increases in striatal dopamine (DA) release. Dopaminergic terminals are, however, present across several associative brain regions, which may contribute to behavioral effects of amphetamine. Yet the assessment of DA release has been restricted to a few brain regions of interest. The present work employed positron emission tomography (PET) with [11C]raclopride to investigate regional and temporal characteristics of amphetamine-induced DA release across twenty sessions in adult female Sprague Dawley rats. Amphetamine was injected intravenously (2 mg/kg) to cause displacement of [11C]raclopride binding from DA D2-like receptors, assessed using temporally sensitive pharmacokinetic PET model (lp-ntPET). We show amphetamine-induced [11C]raclopride displacement in the basal ganglia, and no changes following saline injections. Peak occupancy was highest in nucleus accumbens, followed by caudate-putamen and globus pallidus. Importantly, significant amphetamine-induced displacement was also observed in several extrastriatal regions, and specifically in thalamus, insula, orbitofrontal cortex, and secondary somatosensory area. For these, peak occupancy occurred later and was lower as compared to the striatum. Collectively, these findings demonstrate distinct amphetamine-induced DA responses across the brain, and that [11C]raclopride-PET can be employed to detect such spatiotemporal differences.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Amphetamine
- displacement
- dopamine
- imaging
- receptor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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