Sökning: onr:"swepub:oai:DiVA.org:umu-223843" >
Micro-and mesoscale...
Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation
-
- Valderhaug, Vibeke Devold (författare)
- Department of Research and Innovation, Møre and Romsdal Hospital Trust, Ålesund, Norway; Department of Neuromedicine and Movement Science, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
-
- Ramstad, Ola Huse (författare)
- Department of Neuromedicine and Movement Science, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
-
- van de Wijdeven, Rosanne (författare)
- Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway
-
visa fler...
-
- Heiney, Kristine (författare)
- Department of Computer Science, Faculty of Technology, Art and Design, Oslo Metropolitan University (OsloMet), Oslo, Norway; Department of Computer Science, Faculty of Information Technology and Electrical Engineering, NTNU, Trondheim, Norway
-
- Nichele, Stefano (författare)
- Department of Computer Science, Faculty of Technology, Art and Design, Oslo Metropolitan University (OsloMet), Oslo, Norway; Department of Computer Science and Communication, Østfold University College, Halden, Norway
-
- Sandvig, Axel (författare)
- Umeå universitet,Institutionen för samhällsmedicin och rehabilitering,Department of Neuromedicine and Movement Science, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Clinical Neuroscience, Division of Neuro, Head and Neck, Umeå University Hospital, Umeå, Sweden; Department of Neurology and Clinical Neurophysiology, St Olav’s Hospital, Trondheim, Norway
-
- Sandvig, Ioanna (författare)
- Department of Neuromedicine and Movement Science, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
-
visa färre...
-
(creator_code:org_t)
- Frontiers Media S.A. 2024
- 2024
- Engelska.
-
Ingår i: Frontiers in Cellular Neuroscience. - : Frontiers Media S.A.. - 1662-5102. ; 18
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been extensively studied, yet the wide variety of cellular and network events related to these mutations remain poorly understood. The advancement and availability of tools for neural engineering now enable modeling of selected pathological aspects of neurodegenerative disease in human neural networks in vitro. Our study revealed distinct pathology associated dynamics in engineered human cortical neural networks carrying the LRRK2 G2019S mutation compared to healthy isogenic control neural networks. The neurons carrying the LRRK2 G2019S mutation self-organized into networks with aberrant morphology and mitochondrial dynamics, affecting emerging structure–function relationships both at the micro-and mesoscale. Taken together, the findings of our study points toward an overall heightened metabolic demand in networks carrying the LRRK2 G2019S mutation, as well as a resilience to change in response to perturbation, compared to healthy isogenic controls.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- human neural networks
- LRRK2 G2019S mutation
- mitochondrial dynamics
- neurodegenerative disease model
- Parkinsons disease (PD)
- structure–function
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas