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  • Mayén, Ana-LuciaNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)

Hepatic steatosis, metabolic dysfunction and risk of mortality : findings from a multinational prospective cohort study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • BioMed Central (BMC),2024
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-225965
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-225965URI
  • https://doi.org/10.1186/s12916-024-03366-3DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are implicated in the aetiology of non-communicable diseases. Our study aimed to evaluate associations between NAFLD and MetS with overall and cause-specific mortality.METHODS: We used dietary, lifestyle, anthropometric and metabolic biomarker data from a random subsample of 15,784 EPIC cohort participants. NAFLD was assessed using the fatty liver index (FLI) and MetS using the revised definition. Indices for metabolic dysfunction-associated fatty liver disease (MAFLD) were calculated. The individual associations of these indices with overall and cause-specific mortality were assessed using multivariable Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs). As a subobjective, risk associations with adaptations of new classifications of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic and alcohol-related liver disease (MetALD) were also assessed.RESULTS: Among the 15,784 sub-cohort participants, a total of 1997 deaths occurred (835 due to cancer, 520 to CVD, 642 to other causes) over a median 15.6 (IQR, 12.3-17.1) years of follow-up. Compared to an FLI < 30, FLI ≥ 60 was associated with increased risks of overall mortality (HR = 1.44, 95%CI = 1.27-1.63), and deaths from cancer (HR = 1.32, 95%CI = 1.09-1.60), CVD (HR = 2.06, 95% CI = 1.61-2.63) or other causes (HR = 1.21, 95%CI = 0.97-1.51). Mortality risk associations were also elevated for individuals with MAFLD compared to those without. Individuals with MetS were at increased risk of all mortality endpoints, except cancer-specific mortality. MASLD and MetALD were associated with higher risk of overall mortality.CONCLUSIONS: Our findings based on a prospective cohort suggest that individuals with hepatic steatosis or metabolic dysfunction have a higher overall and cause-specific mortality risk.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sabra, MirnaNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Aglago, Elom K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Perlemuter, GabrielINSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France (författare)
  • Voican, CosminINSERM U996, DHU HepatinovLabex LERMIT, Intestinal Microbiota, Clamart, France; Faculté de Médecine Paris-Sud, Univ Paris-Sud, Université Paris-Saclay ,Le Kremlin-Bicêtre, France; Service d'hépato-Gastroentérologie, Hôpital Antoine-Béclère, Hôpitaux Universitaires Paris-Sud, Assistance Publique-Hôpitaux de Paris, Clamart, France (författare)
  • Ramos, InesNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Debras, CharlotteNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Blanco, JessicaNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Viallon, VivianNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Ferrari, PietroNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Olsen, AnjaDanish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark (författare)
  • Tjønneland, AnneDanish Cancer Society Research Center, Diet, Cancer and Health, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark (författare)
  • Langmann, FieDepartment of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark (författare)
  • Dahm, Christina C.Department of Public Health, Aarhus University, Aarhus C, Bartholins Alle 2, Denmark (författare)
  • Rothwell, JosephUVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France (författare)
  • Laouali, NasserUVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France (författare)
  • Marques, ChloéUVSQ, CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France (författare)
  • Schulze, Matthias B.Dept. of Molecular Epidemiology, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, Germany (författare)
  • Katzke, VerenaDepartment of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Kaaks, RudolfDepartment of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Palli, DomenicoCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (författare)
  • Macciotta, AlessandraDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, Public Health (C-BEPH), University of Turin, Turin, Italy (författare)
  • Panico, SalvatoreDipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy (författare)
  • Tumino, RosarioHyblean Association for Epidemiological Research, Ragusa, Italy (författare)
  • Agnoli, ClaudiaDepartment of Research Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy (författare)
  • Farràs, MartaUnit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain (författare)
  • Molina-Montes, EstherDepartment of Nutrition and Food Science, Campus of Cartuja, University of Granada, Granada, Spain; Spanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación Biosanitaria Ibs. Granada, Granada, Spain; Institute of Nutrition and Food Technology (INYTA) 'José Mataix', Biomedical Research Centre, University of Granada, Granada, Spain (författare)
  • Amiano, PilarSpanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain (författare)
  • Chirlaque, María-DoloresSpanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain (författare)
  • Castilla, JesúsSpanish Consortium for Research On Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Navarra Public Health Institute - IdiSNA, Pamplona, Spain (författare)
  • Werner, MårtenUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)manwer04 (författare)
  • Bodén, StinaUmeå universitet,Pediatrik(Swepub:umu)stabon98 (författare)
  • Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Tsilidis, KostasDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Ullevål, Oslo, Norway (författare)
  • Weiderpass, ElisabeteOffice of the Director, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Freisling, HeinzNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Gunter, Marc J.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (författare)
  • Jenab, MazdaNutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, France (författare)
  • Nutrition and Metabolism Branch, International Agency for Research On Cancer (IARC-WHO), Lyon, FranceDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Medicine: BioMed Central (BMC)22:11741-7015

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