Panel stacking is a threat to consensus statement validity

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Kepp, Kasper P.Meta-Research Innovation Center at Stanford, Stanford University, CA, Stanford, United States (författare)

Panel stacking is a threat to consensus statement validity

Artikel/kapitelEngelska2024

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Elsevier,2024
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LIBRIS-ID:oai:DiVA.org:umu-227910
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-227910URI
https://doi.org/10.1016/j.jclinepi.2024.111428DOI

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Språk:engelska
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Consensus statements can be very influential in medicine and public health. Some of these statements use systematic evidence synthesis but others fail on this front. Many consensus statements use panels of experts to deduce perceived consensus through Delphi processes. We argue that stacking of panel members toward one particular position or narrative is a major threat, especially in absence of systematic evidence review. Stacking may involve financial conflicts of interest, but nonfinancial conflicts of strong advocacy can also cause major bias. Given their emerging importance, we describe here how such consensus statements may be misleading, by analyzing in depth a recent high-impact Delphi consensus statement on COVID-19 recommendations as a case example. We demonstrate that many of the selected panel members and at least 35% of the core panel members had advocated toward COVID-19 elimination (Zero-COVID) during the pandemic and were leading members of aggressive advocacy groups. These advocacy conflicts were not declared in the Delphi consensus publication, with rare exceptions. Therefore, we propose that consensus statements should always require rigorous evidence synthesis and maximal transparency on potential biases toward advocacy or lobbyist groups to be valid. While advocacy can have many important functions, its biased impact on consensus panels should be carefully avoided.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Competing interests
Consensus statements
Evidence based medicine
Guidelines
Panel bias
Transparency

Biuppslag (personer, institutioner, konferenser, titlar ...)

Aavitsland, PrebenPandemic Centre, University of Bergen, Bergen, Norway; Norwegian Institute of Public Health, Oslo, Norway (författare)
Ballin, MarcelCentre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden; Department of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden (författare)
Balloux, FrancoisUCL Genetics Institute, University College London, London, United Kingdom (författare)
Baral, StefanDepartment of Epidemiology, Johns Hopkins School of Public Health, MD, Baltimore, United States; Department of International Health, Johns Hopkins School of Public Health, MD, Baltimore, United States; Department of Health, Policy, and Management, Johns Hopkins School of Public Health, MD, Baltimore, United States (författare)
Bardosh, KevinSchool of Public Health, University of Washington, WA, Seattle, United States; Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom (författare)
Bauchner, HowardDepartment of Pediatrics, Boston University School of Medicine, MA, Boston, United States (författare)
Bendavid, EranDepartment of Medicine (Primary Care and Population Health), Stanford University School of Medicine, CA, Stanford, United States; Department of Health Policy, Stanford University School of Medicine, CA, Stanford, United States; Freeman Spogli Institute for International Studies, Stanford University, CA, Stanford, United States (författare)
Bhopal, RajUsher Institute, University of Edinburgh, Edinburgh, United Kingdom (författare)
Blumstein, Daniel T.Department of Ecology & Evolutionary Biology, Institute of the Environment & Sustainability, University of California Los Angeles, CA, Los Angeles, United States (författare)
Boffetta, PaoloDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; Stony Brook Cancer Center, Stony Brook University, NY, Stony Brook, United States (författare)
Bourgeois, FlorenceDepartment of Pediatrics, Harvard Medical School, MA, Boston, United States (författare)
Brufsky, AdamDivision of Hematology-Oncology, Department of Medicine, University of Pittsburgh, PA, Pittsburgh, United States (författare)
Collignon, Peter J.Department of Infectious Diseases and Microbiology, Canberra Hospital, Australian Capital Territory, Garran, Australia; Department of Infectious Disease, Medical School, Australian National University, Australian Capital Territory, Acton, Australia (författare)
Cripps, SallyHuman Technology Institute, University of Technology Sydney, Sydney, Australia (författare)
Cristea, Ioana A.Department of General Psychology, University of Padova, Padova, Italy (författare)
Curtis, NigelDepartment of Paediatrics, The University of Melbourne, Parkville, Australia; Infectious Diseases Research Group, Murdoch Children's Research Institute, Parkville, Australia; Infectious Diseases Unit, The Royal Children's Hospital Melbourne, Parkville, Australia (författare)
Djulbegovic, BenjaminDivision of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, SC, Charleston, United States (författare)
Faude, OliverDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland (författare)
Flacco, Maria ElenaDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy (författare)
Guyatt, Gordon H.Faculty of Health Sciences, Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Hamilton, Canada; Faculty of Health Sciences, Department of Medicine, McMaster University, ON, Hamilton, Canada (författare)
Hajishengallis, GeorgeDepartment of Basic and Translational Sciences, Penn Dental Medicine, University of Pennsylvania, PA, Philadelphia, United States (författare)
Hemkens, Lars G.Department of Clinical Research, University Hospital Basel, University of Basel, Basel, Switzerland (författare)
Hoffmann, TammyFaculty of Health Sciences and Medicine, Institute for Evidence-Based Healthcare, Bond University, QLD, Robina, Australia (författare)
Joffe, Ari R.Department of Pediatrics and John Dossetor Health Ethics Center, University of Alberta, AB, Edmonton, Canada (författare)
Klassen, Terry P.Children's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, MB, Winnipeg, Canada (författare)
Koletsi, DespinaClinic of Orthodontics and Pediatric Dentistry, Center of Dental Medicine, University of Zurich, Zurich, Switzerland (författare)
Kontoyiannis, Dimitrios P.Division of Internal Medicine, Department of Infectious Diseases, Infection Control, and Employee Health, University of Texas MD Anderson Cancer Center, TX, Houston, United States (författare)
Kuhl, EllenDepartments of Mechanical Engineering and of Bioengineering, Stanford University, CA, Stanford, United States (författare)
La Vecchia, CarloDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milano, Italy (författare)
Lallukka, TeaDepartment of Public Health, University of Helsinki, Helsinki, Finland (författare)
Lambris, JohnDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, Philadelphia, United States (författare)
Levitt, MichaelDepartment of Structural Biology, Stanford University School of Medicine, CA, Stanford, United States (författare)
Makridakis, SpyrosInstitute For the Future (IFF), University of Nicosia, Nicosia, Cyprus (författare)
Maltezou, Helena C.Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece (författare)
Manzoli, LambertoDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, Italy (författare)
Marusic, AnaDepartment of Research in Biomedicine and Health and Center for Evidence-based Medicine, University of Split School of Medicine, Split, Croatia (författare)
Mavragani, ClioDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece (författare)
Moher, DavidCentre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, ON, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, ON, Ottawa, Canada (författare)
Mol, Ben W.Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia (författare)
Muka, TaulantEpistudia, Bern, Switzerland (författare)
Naudet, FlorianResearch Institute for Environmental and Occupational Health (IRSET, UMR_S INSERM 1085), University of Rennes, Rennes, France; Institut Universitaire de France, Paris, France; Clinical Investigation Center (INSERM CIC 1414) and Adult Psychiatry Department, Rennes University Hospital, Rennes, France (författare)
Noble, Paul W.Department of Medicine, Women's Guild Lung Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States (författare)
Nordström, AnnaUmeå universitet,Institutionen för folkhälsa och klinisk medicin,School of Sport Sciences, UiT the Arctic University of Norway, Tromsø, Norway; Department of Health Sciences, The Swedish Winter Sport Research Centre, Mid Sweden University, Östersund, Sweden(Swepub:umu)anagun97 (författare)
Nordström, PeterDepartment of Public Health and Caring Sciences, Clinical Geriatrics, Uppsala University, Uppsala, Sweden (författare)
Pandis, NikolaosDepartment of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Bern, Switzerland (författare)
Papatheodorou, StefaniaDepartment of Biostatistics and Epidemiology, Rutgers School of Public Health, NJ, Piscataway, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
Patel, Chirag J.Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States (författare)
Petersen, IreneDepartment of Primary Care and Population Health, University College London, London, United Kingdom (författare)
Pilz, StefanDivision Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria (författare)
Plesnila, NikolausInstitute for Stroke and Dementia Research (ISD), Ludwig-Maximilians-University Munich, Munich, Germany; Munich Cluster for Systems Neurology (Synergy), Munich, Germany (författare)
Ponsonby, Anne-LouiseThe Florey Institute of Neuroscience and Mental Health, Melbourne, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia; Centre of Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Australia (författare)
Rivas, Manuel A.Department of Biomedical Data Science, Stanford University School of Medicine, CA, Stanford, United States (författare)
Saltelli, AndreaUPF Barcelona School of Management, Barcelona, Spain; Centre for the Study of the Sciences and the Humanities, University of Bergen, Bergen, Norway (författare)
Schabus, ManuelDepartment of Psychology, University of Salzburg, Salzburg, Austria (författare)
Schippers, Michaéla C.Department of Organisation and Personnel Management, Erasmus University Rotterdam, Rotterdam, Netherlands (författare)
Schünemann, HolgerFaculty of Health Sciences, Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Hamilton, Canada (författare)
Solmi, MarcoDepartment of Psychiatry, University of Ottawa, ON, Ottawa, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany (författare)
Stang, AndreasInstitute of Medical Informatics, Biometry and Epidemiology, University Hospital Essen, Essen, Germany (författare)
Streeck, HendrikFaculty of Medicine, Institute of Virology, University of Bonn, Bonn, Germany (författare)
Sturmberg, Joachim P.College of Health, Medicine and Wellbeing, University of Newcastle, NSW, Holgate, Australia; International Society for Systems and Complexity Sciences for Health, VT, Waitsfield, United States (författare)
Thabane, LehanaFaculty of Health Sciences, Department of Health Research Methods, Evidence and Impact, McMaster University, ON, Hamilton, Canada (författare)
Thombs, Brett D.Lady Davis Institute for Medical Research, Jewish General Hospital, QC, Montreal, Canada; Department of Psychiatry, McGill University, QC, Montreal, Canada; Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, QC, Montreal, Canada; Department of Medicine, McGill University, QC, Montreal, Canada; Biomedical Ethics Unit, McGill University, QC, Montreal, Canada; Department of Psychology, McGill University, QC, Montreal, Canada (författare)
Tsakris, AthanasiosDepartment of Microbiology, Medical School, University of Athens, Athens, Greece (författare)
Wood, Simon N.Chair of Computational Statistics, School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom (författare)
Ioannidis, John P.A.Meta-Research Innovation Center at Stanford, Stanford University, CA, Stanford, United States; Department of Biomedical Data Science, Stanford University School of Medicine, CA, Stanford, United States; Department of Medicine (Stanford Prevention Research Center), Stanford University School of Medicine, CA, Stanford, United States; Department of Epidemiology and Population Health, Stanford University School of Medicine, CA, Stanford, United States; Department of Statistics, Stanford University School of Humanities and Sciences, CA, Stanford, United States (författare)
Meta-Research Innovation Center at Stanford, Stanford University, CA, Stanford, United StatesPandemic Centre, University of Bergen, Bergen, Norway; Norwegian Institute of Public Health, Oslo, Norway (creator_code:org_t)

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Ingår i:Journal of Clinical Epidemiology: Elsevier1730895-43561878-5921

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Av författaren/redakt...: Kepp, Kasper P.; Aavitsland, Preb ...; Ballin, Marcel; Balloux, Francoi ...; Baral, Stefan; Bardosh, Kevin; visa fler...; Bauchner, Howard; Bendavid, Eran; Bhopal, Raj; Blumstein, Danie ...; Boffetta, Paolo; Bourgeois, Flore ...; Brufsky, Adam; Collignon, Peter ...; Cripps, Sally; Cristea, Ioana A ...; Curtis, Nigel; Djulbegovic, Ben ...; Faude, Oliver; Flacco, Maria El ...; Guyatt, Gordon H ...; Hajishengallis, ...; Hemkens, Lars G.; Hoffmann, Tammy; Joffe, Ari R.; Klassen, Terry P ...; Koletsi, Despina; Kontoyiannis, Di ...; Kuhl, Ellen; La Vecchia, Carl ...; Lallukka, Tea; Lambris, John; Levitt, Michael; Makridakis, Spyr ...; Maltezou, Helena ...; Manzoli, Lambert ...; Marusic, Ana; Mavragani, Clio; Moher, David; Mol, Ben W.; Muka, Taulant; Naudet, Florian; Noble, Paul W.; Nordström, Anna; Nordström, Peter; Pandis, Nikolaos; Papatheodorou, S ...; Patel, Chirag J.; Petersen, Irene; Pilz, Stefan; Plesnila, Nikola ...; Ponsonby, Anne-L ...; Rivas, Manuel A.; Saltelli, Andrea; Schabus, Manuel; Schippers, Micha ...; Schünemann, Holg ...; Solmi, Marco; Stang, Andreas; Streeck, Hendrik; Sturmberg, Joach ...; Thabane, Lehana; Thombs, Brett D.; Tsakris, Athanas ...; Wood, Simon N.; Ioannidis, John ...; visa färre...

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