Sökning: onr:"swepub:oai:DiVA.org:umu-32924" > Effects of atenolol...
Fältnamn | Indikatorer | Metadata |
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000 | 03467naa a2200457 4500 | |
001 | oai:DiVA.org:umu-32924 | |
003 | SwePub | |
008 | 100331s2010 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/108915 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-329242 URI |
024 | 7 | a https://doi.org/10.1177/10760296093495012 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/1089152 URI |
040 | a (SwePub)umud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boman, Kurtu Umeå universitet,Medicin4 aut0 (Swepub:umu)kubo0001 |
245 | 1 0 | a Effects of atenolol or losartan on fibrinolysis and von Willebrand factor in hypertensive patients with left ventricular hypertrophy. |
264 | c 2009-10-13 | |
264 | 1 | b SAGE Publications,c 2010 |
338 | a print2 rdacarrier | |
520 | a OBJECTIVES: To compare the effects of the beta-blocker atenolol with the angiotensin receptor blocker (ARB) losartan on plasma tissue-type plasminogen activator (tPA) activity and mass concentration, plasminogen activator inhibitor-1 (PAI-1) activity, tPA/PAI-1 complex, and von Willebrand factor (VWF). DESIGN: A prespecified, explorative substudy in 22 patients with hypertension and left ventricular hypertrophy (LVH) performed within randomized multicenter, double-blind prospective study. RESULTS: After a median of 36 weeks of treatment, there were significant differences between the treatment groups, atenolol versus losartan, in plasma median levels of tPA mass (11.9 vs 7.3 ng/mL, P = .019), PAI-1 activity (20.7 vs 4.8 IU/mL, P = .030), and tPA/PAI-1 complex (7.1 vs 2.5 ng/mL, P = .015). In patients treated with atenolol, median levels of tPA mass (8.9-11.9 ng/mL, P = .021) and VWF (113.5%-134.3%, P = .021) increased significantly, indicating a change toward a more prothrombotic state. No significant changes occurred in the losartan group. CONCLUSION: Losartan treatment was associated with preserved fibrinolytic balance compared to a more prothrombotic fibrinolytic and hemostatic state in the atenolol group. These findings suggest different fibrinolytic and hemostatic responses to treatment in hypertensive patients with LVH. | |
653 | a fibrinolysis | |
653 | a von Willebrand factor | |
653 | a hypertension | |
653 | a left ventricular hypertrophy | |
653 | a atenolol | |
653 | a losartan | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Boman, Jenny Hernestålu Umeå universitet,Medicin4 aut0 (Swepub:umu)jeyhel99 |
700 | 1 | a Andersson, Jonas,d 1977-u Umeå universitet,Medicin4 aut0 (Swepub:umu)jasaon96 |
700 | 1 | a Olofsson, Mona,d 1952-u Umeå universitet,Medicin4 aut0 (Swepub:umu)mool0019 |
700 | 1 | a Dahlöf, Björn,d 1953u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine4 aut0 (Swepub:gu)xdahbj |
710 | 2 | a Umeå universitetb Medicin4 org |
773 | 0 | t Clinical and applied thrombosis/hemostasisd : SAGE Publicationsg 16:2, s. 146-152q 16:2<146-152x 1076-0296x 1938-2723 |
856 | 4 | u http://journals.sagepub.com/doi/pdf/10.1177/1076029609349501 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32924 |
856 | 4 8 | u https://doi.org/10.1177/1076029609349501 |
856 | 4 8 | u https://gup.ub.gu.se/publication/108915 |
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