Sökning: onr:"swepub:oai:DiVA.org:umu-35270" > Oxazole-modified gl...
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000 | 02983naa a2200361 4500 | |
001 | oai:DiVA.org:umu-35270 | |
003 | SwePub | |
008 | 100811s2010 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:120868293 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-352702 URI |
024 | 7 | a https://doi.org/10.1039/c003640d2 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1208682932 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andersson, Ida E.,d 1982-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)idaann02 |
245 | 1 0 | a Oxazole-modified glycopeptides that target arthritis-associated class II MHC Aq and DR4 proteins |
264 | 1 | b RSC Publishing,c 2010 |
338 | a print2 rdacarrier | |
520 | a The glycopeptide CII259-273, a fragment from type II collagen (CII), can induce tolerance in mice susceptible to collagen-induced arthritis (CIA), which is a validated disease model for rheumatoid arthritis (RA). Here, we describe the design and synthesis of a small series of modified CII259-273 glycopeptides with oxazole heterocycles replacing three potentially labile peptide bonds. These glycopeptidomimetics were evaluated for binding to murine CIA-associated A(q) and human RA-associated DR4 class II major histocompatibility complex (MHC) proteins. The oxazole modifications drastically reduced or completely abolished binding to A(q). Two of the glycopeptidomimetics were, however, well tolerated in binding to DR4 and they also induced strong responses by one or two DR4-restricted T-cell hybridomas. This work contributes to the development of an altered glycopeptide for inducing immunological tolerance in CIA, with the long-term goal of developing a therapeutic vaccine for treatment of RA. | |
700 | 1 | a Batsalova, Tsvetelinau Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut |
700 | 1 | a Dzhambazov, Baliku Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden4 aut |
700 | 1 | a Edvinsson, Lottau Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)loed0002 |
700 | 1 | a Holmdahl, Rikardu Karolinska Institutet4 aut |
700 | 1 | a Kihlberg, Jan,d 1957-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)jaki0001 |
700 | 1 | a Linusson, Anna,d 1970-u Umeå universitet,Kemiska institutionen4 aut0 (Swepub:umu)analin99 |
710 | 2 | a Umeå universitetb Kemiska institutionen4 org |
773 | 0 | t Organic and biomolecular chemistryd : RSC Publishingg 8:13, s. 2931-2940q 8:13<2931-2940x 1477-0520x 1477-0539 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35270 |
856 | 4 8 | u https://doi.org/10.1039/c003640d |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120868293 |
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