Sökning: onr:"swepub:oai:DiVA.org:umu-36102" > Circulating C-react...
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000 | 04936naa a2200937 4500 | |
001 | oai:DiVA.org:umu-36102 | |
003 | SwePub | |
008 | 100917s2010 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-361022 URI |
024 | 7 | a https://doi.org/10.1093/aje/kwq1352 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aleksandrova, Krasimira4 aut |
245 | 1 0 | a Circulating C-reactive protein concentrations and risks of colon and rectal cancer :b a nested case-control study within the European Prospective Investigation into Cancer and Nutrition |
264 | c 2010-07-15 | |
264 | 1 | b Oxford University Press (OUP),c 2010 |
338 | a print2 rdacarrier | |
520 | a The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of > or = 3.0 mg/L versus <1.0 mg/L were 1.36 (95% confidence interval (CI): 1.00, 1.85; P-trend = 0.01) for colon cancer and 1.02 (95% CI: 0.67, 1.57; P-trend = 0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk = 1.74, 95% CI: 1.11, 2.73; P-trend = 0.01) but not in women (relative risk = 1.06, 95% CI: 0.67, 1.68; P-trend = 0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. These data provide evidence that elevated CRP concentrations are related to a higher risk of colon cancer but not rectal cancer, predominantly among men and independently of obesity, insulin resistance, and dyslipidemia. | |
650 | 7 | a LANTBRUKSVETENSKAPERx Veterinärmedicinx Patobiologi0 (SwePub)403022 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Veterinary Sciencex Pathobiology0 (SwePub)403022 hsv//eng |
653 | a colorectal neoplasms | |
653 | a C-reactive protein | |
653 | a hyperglycemia | |
653 | a hyperinsulinism | |
653 | a hyperlipidemias | |
653 | a inflammation | |
653 | a obesity | |
653 | a abdominal | |
653 | a Pathology | |
653 | a Patologi | |
653 | a Pathology | |
653 | a patologi | |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Jansen, Eugene4 aut |
700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
700 | 1 | a Rinaldi, Sabina4 aut |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Dahm, Christina C4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Tjønneland, Anne4 aut |
700 | 1 | a Boutron-Ruault, Marie-Christine4 aut |
700 | 1 | a Clavel-Chapelon, Françoise4 aut |
700 | 1 | a Morois, Sophie4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Krogh, Vittorio4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Rohrmann, Sabine4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a van Duijnhoven, Fränzel JB4 aut |
700 | 1 | a Leufkens, Anke M4 aut |
700 | 1 | a Peeters, Petra H4 aut |
700 | 1 | a Rodríguez, Laudina4 aut |
700 | 1 | a Bonet, Catalina4 aut |
700 | 1 | a Sánchez, María-José4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Navarro, Carmen4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001 |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nicholas4 aut |
700 | 1 | a Allen, Naomi E4 aut |
700 | 1 | a Spencer, Elizabeth4 aut |
700 | 1 | a Romaguera, Dora4 aut |
700 | 1 | a Norat, Teresa4 aut |
700 | 1 | a Pischon, Tobias4 aut |
710 | 2 | a Umeå universitetb Patologi4 org |
773 | 0 | t American Journal of Epidemiologyd : Oxford University Press (OUP)g 172:4, s. 407-418q 172:4<407-418x 0002-9262x 1476-6256 |
856 | 4 | u https://academic.oup.com/aje/article-pdf/172/4/407/192056/kwq135.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-36102 |
856 | 4 8 | u https://doi.org/10.1093/aje/kwq135 |
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