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In vitro cellular d...
In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia
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- Lönnerholm, Gudmar, 1941- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer
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- Thörn, Ingrid (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Frost, Britt-Marie, 1955- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer
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- Flaegstad, Trond (author)
- Departmnt of Pediatrics, University and University Hospital, Tromsoe, Norway
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- Heyman, Mats (author)
- Karolinska Institutet
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- Jonsson, Olafur Gisli (author)
- Department of Pediatrics, Landspitalinn, Reykjavik, Iceland
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- Harila-Saari, Arja (author)
- Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland
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- Madsen, Hans O (author)
- Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
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- Porwit, Anna (author)
- Karolinska Institutet
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- Schmiegelow, Kjeld (author)
- Pediatric Clinic II, Rigshospitalet, Copenhagen, Denmark
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- Söderhäll, Stefan (author)
- Karolinska Institutet
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- Wesenberg, Finn (author)
- Department of Pediatrics, National Hospital, Oslo, Norway
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- Vettenranta, Kim (author)
- Department of Pediatrics, University of Tampere, Finland
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- Larsson, Rolf (author)
- Uppsala universitet,Klinisk farmakologi,Cancer Pharmacology and Informatics/Rolf Larsson
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- Forestier, Erik (author)
- Umeå universitet,Pediatrik,Department of Clinical Sciences, Paediatrics, University of Umeå, Sweden
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(creator_code:org_t)
- Elsevier, 2011
- 2011
- English.
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In: Leukemia Research. - : Elsevier. - 0145-2126 .- 1873-5835. ; 35:4, s. 472-478
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD <0.1% day 29. The risk of any relapse was correlated to vincristine and doxorubicin resistance, with a relative risk of 3.7 (95% CI 1.3-10.5; p=0.016) for patients resistant to both drugs. There was a significant correlation also for the subgroup with extra-medullary relapses. Our findings indicate that analysis of drug resistance can add prognostic information to other known risk-factors including MRD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- acute lymphoblastic leukemia
- childhood
- in vitro drug resistance
- MRD
- prognostic factors
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Lönnerholm, Gudm ...
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Thörn, Ingrid
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Sundström, Chris ...
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Frost, Britt-Mar ...
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Flaegstad, Trond
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Heyman, Mats
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Jonsson, Olafur ...
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Harila-Saari, Ar ...
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Madsen, Hans O
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Porwit, Anna
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Schmiegelow, Kje ...
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Söderhäll, Stefa ...
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Wesenberg, Finn
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Vettenranta, Kim
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Larsson, Rolf
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Forestier, Erik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia Researc ...
- By the university
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Umeå University
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Uppsala University
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Karolinska Institutet