Sökning: onr:"swepub:oai:DiVA.org:umu-3836" > The spontaneous pol...
Fältnamn | Indikatorer | Metadata |
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000 | 02474naa a2200337 4500 | |
001 | oai:DiVA.org:umu-3836 | |
003 | SwePub | |
008 | 040330s2003 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38362 URI |
024 | 7 | a https://doi.org/10.1016/S0014-5793(03)00057-72 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Wilczynska, Malgorzatau Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)mawi0006 |
245 | 1 0 | a The spontaneous polymerization of plasminogen activator inhibitor type-2 and Z-antitrypsin are due to different molecular aberrations |
264 | 1 | c 2003 |
338 | a print2 rdacarrier | |
520 | a The wild-type form of plasminogen activator inhibitor type-2 (PAI-2) and the pathogenic Z-mutant of alpha(1)-antitrypsin (alpha(1)AT) are serpins that spontaneously polymerize by the loop-sheet mechanism. Compared to the consensus serpin sequence, both PAI-2 and Z-alpha(1)AT have deviations in the so-called breach region located at the top of the A beta-sheet. In the case of Z-alpha(1)AT, conformational perturbations caused by a single amino acid substitution result in polymerization in vivo and predisposes to disease. To test whether the polymerization of PAI-2 is due to aberrations in the breach region, we constructed substitution mutants of PAI-2 with conserved residues in this region. Analysis of the mutants revealed that deviations in the breach region modulate but are not the major cause of PAI-2 polymerization. Rather, PAI-2 exists in a highly polymerogenic conformation and does not require conformational rearrangements before polymerization can take place. | |
653 | a Serpin | |
653 | a Loop–sheet polymerization | |
653 | a Plasminogen activator inhibitor type-2 | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Lobov, Sergeiu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
700 | 1 | a Ny, Toru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)tony0001 |
710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
773 | 0 | t FEBS Lettersg 537:1-3, s. 11-16q 537:1-3<11-16x 0014-5793x 1873-3468 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3836 |
856 | 4 8 | u https://doi.org/10.1016/S0014-5793(03)00057-7 |
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