Sökning: onr:"swepub:oai:DiVA.org:umu-42155" > Superoxide dismutas...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04319naa a2200541 4500 | |
001 | oai:DiVA.org:umu-42155 | |
003 | SwePub | |
008 | 110406s2010 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:kth-79022 | |
009 | oai:slubar.slu.se:61127 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-421552 URI |
024 | 7 | a https://doi.org/10.1111/j.1471-4159.2010.06753.x2 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-790222 URI |
024 | 7 | a https://res.slu.se/id/publ/611272 URI |
040 | a (SwePub)umud (SwePub)kthd (SwePub)slu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Bergemalm, Danielu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)dalbem99 |
245 | 1 0 | a Superoxide dismutase-1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice |
264 | c 2010-04-19 | |
264 | 1 | b Wiley,c 2010 |
338 | a print2 rdacarrier | |
500 | a QC 20120216 | |
520 | a Mutant superoxide dismutase-1 (SOD1) causes amyotrophic lateral sclerosis (ALS) through a cytotoxic mechanism of unknown nature. A hallmark in ALS patients and transgenic mouse models carrying human SOD1 (hSOD1) mutations are hSOD1-immunoreactive inclusions in spinal cord ventral horns. The hSOD1 inclusions may block essential cellular functions or cause toxicity through sequestering of other proteins. Inclusions from four different transgenic mouse models were examined after density gradient ultracentrifugation. The inclusions are complex structures with heterogeneous densities and are disrupted by detergents. The aggregated hSOD1 was mainly composed of subunits that lacked the native stabilizing intra-subunit disulfide bond. A proportion of subunits formed hSOD1 oligomers or was bound to other proteins through disulfide bonds. Dense inclusions could be isolated and the protein composition was analyzed using proteomic techniques. Mutant hSOD1 accounted for half of the protein. Ten other proteins were identified. Two were cytoplasmic chaperones, four were cytoskeletal proteins, and 4 were proteins that normally reside in the endoplasmic reticulum (ER). The presence of ER proteins in inclusions containing the primarily cytosolic hSOD1 further supports the notion that ER stress is involved in ALS. | |
650 | 7 | a LANTBRUKSVETENSKAPERx Lantbruksvetenskap, skogsbruk och fiskex Jordbruksvetenskap0 (SwePub)401012 hsv//swe |
650 | 7 | a AGRICULTURAL SCIENCESx Agriculture, Forestry and Fisheriesx Agricultural Science0 (SwePub)401012 hsv//eng |
653 | a amyotrophic lateral sclerosis;endoplasmic reticulum;inclusion;proteomics;superoxide dismutase-1;transgenic mice | |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a medicin | |
653 | a Medicine | |
700 | 1 | a Forsberg, Karinu Umeå universitet,Patologi,Thomas Brännström4 aut0 (Swepub:umu)nonkin02 |
700 | 1 | a Srivastava, Vaibhavu Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology4 aut0 (Swepub:slu)52285 |
700 | 1 | a Graffmo, Karin Su Umeå universitet,Patologi4 aut0 (Swepub:umu)kanerl79 |
700 | 1 | a Andersen, Peter Mu Umeå universitet,Neurologi4 aut0 (Swepub:umu)pean0001 |
700 | 1 | a Brännström, Thomasu Umeå universitet,Patologi4 aut0 (Swepub:umu)thbr0001 |
700 | 1 | a Wingsle, Gunnaru Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för skoglig genetik och växtfysiologi,Department of Forest Genetics and Plant Physiology4 aut0 (Swepub:slu)48677 |
700 | 1 | a Marklund, Stefan Lu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)stma0003 |
710 | 2 | a Umeå universitetb Klinisk kemi4 org |
710 | 2 | a Sveriges lantbruksuniversitet |
773 | 0 | t Journal of Neurochemistryd : Wileyg 114:2, s. 408-418q 114:2<408-418x 0022-3042x 1471-4159 |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1471-4159.2010.06753.x |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42155 |
856 | 4 8 | u https://doi.org/10.1111/j.1471-4159.2010.06753.x |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-79022 |
856 | 4 8 | u https://res.slu.se/id/publ/61127 |
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