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Bordetella pertussi...
Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine : comparison of the T cell cytokine profiles in infants and mice.
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Ryan, M (author)
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- Gothefors, Leif (author)
- Umeå universitet,Pediatrik
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Storsaeter, J (author)
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Mills, K H (author)
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(creator_code:org_t)
- 1997
- 1997
- English.
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In: Developments in biological standardization. - 0301-5149. ; 89, s. 297-305
- Related links:
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https://urn.kb.se/re...
Abstract
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- In an investigation of cell-mediated immunity against Bordetella pertussis, we found that B. pertussis infection in infants and in mice was associated with the induction of antigen-specific T cells that secrete IFN-g and IL-2, but not IL-4 or IL-5. This cytokine profile is characteristic of Th1 cells that mediate cellular immune responses against a range of intracellular pathogens. An examination of cytokine production following immunization with a three-component acellular vaccine, comprising inactive PT, FHA and pertactin adsorbed to alum, demonstrated that spleen cells from vaccinated mice produced high levels of IL-5, but no detectable IFN-g and low levels of IL-2. In contrast, peripheral blood mononuclear cells from vaccinated infants produced IL-2, IL-5 and IFN-g. These findings highlight significant differences in the immune responses generated by vaccination and natural infection with B. pertussis and demonstrate that the T-cell response induced with an acellular vaccine, although dominated by type 2 cytokines in mice, is more heterogeneous in infants with a Th0 or mixed Th1/Th2 cytokine profile.
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