Sökning: onr:"swepub:oai:DiVA.org:umu-50526" > Hepatocellular carc...
Fältnamn | Indikatorer | Metadata |
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000 | 06435naa a2201069 4500 | |
001 | oai:DiVA.org:umu-50526 | |
003 | SwePub | |
008 | 111213s2011 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:83af0069-5283-4599-8887-b0eff0850048 | |
009 | oai:gup.ub.gu.se/161988 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-505262 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djr3952 DOI |
024 | 7 | a https://lup.lub.lu.se/record/22002282 URI |
024 | 7 | a https://gup.ub.gu.se/publication/1619882 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Trichopoulos, Dimitrios4 aut |
245 | 1 0 | a Hepatocellular carcinoma risk factors and disease burden in a European cohort :b a nested case-control study |
264 | c 2011-10-21 | |
264 | 1 | a Oxford :b Oxford University Press,c 2011 |
338 | a print2 rdacarrier | |
520 | a Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.Methods: Using data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.Results: Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95% confidence interval [CI] = 2.10 to 39.50 and OR = 13.36, 95% CI = 4.11 to 43.45, respectively), obesity (OR = 2.13, 95% CI = 1.06 to 4.29), former or current smoking (OR = 1.98, 95% CI = 0.90 to 4.39 and OR = 4.55, 95% CI = 1.90 to 10.91, respectively), and heavy alcohol intake (OR = 1.77, 95% CI = 0.73 to 4.27) were associated with hepatocellular carcinoma. Smoking contributed to almost half of all hepatocellular carcinomas (47.6%), whereas 13.2% and 20.9% were attributable to chronic HBV and HCV infection, respectively. Obesity and heavy alcohol intake contributed 16.1% and 10.2%, respectively. Almost two-thirds (65.7%, 95% CI = 50.6% to 79.3%) of hepatocellular carcinomas can be accounted for by exposure to at least one of these documented risk factors.Conclusions: Smoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng |
653 | a hepatitis-c virus | |
653 | a attributable risk | |
653 | a liver disease | |
653 | a cancer; nutrition | |
653 | a exposure | |
653 | a alcohol | |
653 | a association | |
653 | a population | |
653 | a antibodies | |
700 | 1 | a Bamia, Christina4 aut |
700 | 1 | a Lagiou, Pagona4 aut |
700 | 1 | a Fedirko, Veronika4 aut |
700 | 1 | a Trepo, Elisabeth4 aut |
700 | 1 | a Jenab, Mazda4 aut |
700 | 1 | a Pischon, Tobias4 aut |
700 | 1 | a Noethlings, Ute4 aut |
700 | 1 | a Overved, Kim4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Outzen, Malene4 aut |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
700 | 1 | a Lukanova, Annekatrin4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Aleksandrova, Krasimira4 aut |
700 | 1 | a Benetou, Vassiliki4 aut |
700 | 1 | a Zylis, Dimosthenis4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Pala, Valeria4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Sacerdote, Carlotta4 aut |
700 | 1 | a Bueno-De-Mesquita, H. Bas4 aut |
700 | 1 | a Van Kranen, Henk J.4 aut |
700 | 1 | a Peeters, Petra H. M.4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Ramon Quiros, J.4 aut |
700 | 1 | a Gonzalez, Carlos A.4 aut |
700 | 1 | a Sanchez Perez, Maria-Jose4 aut |
700 | 1 | a Navarro, Carmen4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Barricarte, Aurelio4 aut |
700 | 1 | a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo |
700 | 1 | a Regnér, Sarau Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-sre |
700 | 1 | a Werner, Mårtenu Umeå universitet,Medicin4 aut0 (Swepub:umu)manwer04 |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Wareham, Nick4 aut |
700 | 1 | a Key, Timothy4 aut |
700 | 1 | a Romieu, Isabelle4 aut |
700 | 1 | a Chuang, Shu-Chun4 aut |
700 | 1 | a Murphy, Neil4 aut |
700 | 1 | a Boffetta, Paolo4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Riboli, Elio4 aut |
710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Journal of the National Cancer Instituted Oxford : Oxford University Pressg 103:22, s. 1686-1695q 103:22<1686-1695x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/103/22/1686/7673597/djr395.pdf |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/22021666?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1093/jnci/djr395y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50526 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djr395 |
856 | 4 8 | u https://lup.lub.lu.se/record/2200228 |
856 | 4 8 | u https://gup.ub.gu.se/publication/161988 |
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