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Diabetes mellitus, ...
Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk : a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Grote, V. A. (author)
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Rohrmann, S. (author)
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Nieters, A. (author)
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show more...
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Dossus, L. (author)
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Tjonneland, A. (author)
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Halkjaer, J. (author)
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Overvad, K. (author)
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Fagherazzi, G. (author)
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Boutron-Ruault, M. C. (author)
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Morois, S. (author)
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Teucher, B. (author)
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Becker, S. (author)
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Sluik, D. (author)
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Boeing, H. (author)
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Trichopoulou, A. (author)
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Lagiou, P. (author)
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Trichopoulos, D. (author)
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Palli, D. (author)
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Pala, V. (author)
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Tumino, R. (author)
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Vineis, P. (author)
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Panico, S. (author)
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Rodriguez, L. (author)
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Duell, E. J. (author)
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Molina-Montes, E. (author)
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Dorronsoro, M. (author)
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Huerta, J. M. (author)
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Ardanaz, E. (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Malin Sund
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Beulens, J. W. J. (author)
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Peeters, P. H. M. (author)
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- Sund, Malin, 1972- (author)
- Umeå universitet,Kirurgi,Malin Sund
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- Ye, W. (author)
- Karolinska Institutet
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- Lindkvist, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Johansen, Dorthe (author)
- Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups
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Khaw, K. T. (author)
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Wareham, N. (author)
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Allen, N. (author)
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Crowe, F. (author)
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Jenab, M. (author)
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Romieu, I. (author)
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Michaud, D. S. (author)
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Riboli, E. (author)
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Romaguera, D. (author)
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Bueno-de-Mesquita, H. B. (author)
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Kaaks, R. (author)
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(creator_code:org_t)
- 2011-09-28
- 2011
- English.
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In: Diabetologia. - New York : Springer-Verlag New York. - 0012-186X .- 1432-0428. ; 54:12, s. 3037-3046
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https://link.springe...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Aims/hypothesis: There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) and date of tumour diagnosis.Methods: Pre-diagnostic levels of HbA(1c) and C-peptide were measured for 466 participants with pancreatic cancer and 466 individually matched controls within the European Prospective Investigation into Cancer and Nutrition. Conditional logistic regression models were used to estimate ORs for pancreatic cancer.Results: Pancreatic cancer risk gradually increased with increasing pre-diagnostic HbA(1c) levels up to an OR of 2.42 (95% CI 1.33, 4.39 highest [>= 6.5%, 48 mmol/mol] vs lowest [<= 5.4%, 36 mmol/mol] category), even for individuals with HbA(1c) levels within the non-diabetic range. C-peptide levels showed no significant relationship with pancreatic cancer risk, irrespective of fasting status. Analyses showed no clear trends towards increasing hyperglycaemia (as marked by HbA(1c) levels) or reduced pancreatic beta cell responsiveness (as marked by C-peptide levels) with decreasing time intervals from blood donation to cancer diagnosis.Conclusions/interpretation: Our data on HbA(1c) show that individuals who develop exocrine pancreatic cancer tend to have moderate increases in HbA(1c) levels, relatively independently of obesity and insulin resistance-the classic and major risk factors for type 2 diabetes. While there is no strong difference by lag time, more data are needed on this in order to reach a firm conclusion.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- C-peptide
- HbA(1c)
- Cohort study
- Diabetes
- EPIC
- Pancreatic cancer
- C-peptide
- HbA(1c)
- Cohort study
- Diabetes
- EPIC
- Pancreatic cancer
- c-peptide
- hba(1c)
- cohort study
- diabetes
- epic
- pancreatic cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Grote, V. A.
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Rohrmann, S.
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Nieters, A.
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Dossus, L.
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Tjonneland, A.
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Halkjaer, J.
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show more...
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Overvad, K.
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Fagherazzi, G.
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Boutron-Ruault, ...
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Morois, S.
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Teucher, B.
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Becker, S.
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Sluik, D.
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Boeing, H.
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Trichopoulou, A.
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Lagiou, P.
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Trichopoulos, D.
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Palli, D.
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Pala, V.
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Tumino, R.
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Vineis, P.
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Panico, S.
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Rodriguez, L.
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Duell, E. J.
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Molina-Montes, E ...
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Dorronsoro, M.
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Huerta, J. M.
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Ardanaz, E.
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Sund, Malin, 197 ...
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Beulens, J. W. J ...
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Peeters, P. H. M ...
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Ye, W.
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Lindkvist, Björn
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Johansen, Dorthe
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Khaw, K. T.
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Wareham, N.
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Allen, N.
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Crowe, F.
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Jenab, M.
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Romieu, I.
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Michaud, D. S.
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Riboli, E.
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Romaguera, D.
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Bueno-de-Mesquit ...
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Kaaks, R.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Diabetologia
- By the university
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Umeå University
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Lund University
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Karolinska Institutet
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University of Gothenburg