Search: onr:"swepub:oai:DiVA.org:umu-54401" >
Derivatives of 8-hy...
Derivatives of 8-hydroxyquinoline-antibacterial agents that target intra- and extracellular Gram-negative pathogens
-
- Enquist, Per-Anders (author)
- Umeå universitet,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS),Kemiska institutionen,pa.enquist@chem.umu.se
-
- Gylfe, Åsa (author)
- Umeå universitet,Klinisk bakteriologi
-
- Hägglund, Ulrik (author)
- Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden
-
show more...
-
- Lindström, Pia (author)
- Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden
-
- Norberg-Scherman, Henrik (author)
- Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden
-
- Sundin, Charlotta (author)
- Creative Antibiotics, Tvistevägen 48, SE90719 Umeå, Sweden
-
- Elofsson, Mikael (author)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Molekylär Infektionsmedicin, Sverige (MIMS)
-
show less...
-
(creator_code:org_t)
- Elsevier, 2012
- 2012
- English.
-
In: Bioorganic & Medicinal Chemistry Letters. - : Elsevier. - 0960-894X .- 1464-3405. ; 22:10, s. 3550-3553
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-)methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure-activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database